Abstract
Statins (e.g., simvastatin) have shown to induce expression of the bone morphogenic protein-2 gene in bone cells, but they are not used clinically because of a lack of a suitable delivery device. The overall objective is to develop optimized statin delivery devices for bone regeneration. The specific objective was to determine the effect of grafting statins to biodegradable poly[lactide-co-glycolide] (PLG) on release kinetics. Simvastatin was grafted to PLG (OG-PLG) and characterized using contact-angle measurements, attenuated total reflectance-Fourier transform infrared, and ultraviolet-visible spectroscopy to determine success of the synthesis. An ultraviolet-visible assay for measuring release of statins and degraded OG-PLG in media was also developed. In vitro release studies using films and scaffolds made with PLG, PLG blended with simvastatin (PLG + Sim), and OG-PLG (simvastatin grafted to PLG) blended into PLG at different concentrations showed that release rate of OG-PLG from films was significantly greater than that of PLG + Sim. However, release rate from scaffolds showed PLG + Sim to be significantly higher than that of OG-PLG. The diffusion-controlled release kinetics of simvastatin from PLG + Sim seems to be more heavily affected by device morphology, whereas the degradation-controlled release kinetics seem to be less affected. In short, release kinetics can be modulated by grafting statins to PLG.
Original language | English (US) |
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Pages (from-to) | 237-246 |
Number of pages | 10 |
Journal | Journal of Biomedical Materials Research - Part A |
Volume | 74 |
Issue number | 2 |
DOIs | |
State | Published - Aug 1 2005 |
Keywords
- Bone regeneration
- Controlled delivery
- Poly[lactide-co-glycolide]
- Statin
- Synthesis and characterization
ASJC Scopus subject areas
- Ceramics and Composites
- Metals and Alloys
- Biomedical Engineering
- Biomaterials