TY - JOUR
T1 - Yeast DNA repair protein RAD23 promotes complex formation between transcription factor TFIIH and DNA damage recognition factor RAD14
AU - Guzder, Sami N.
AU - Bailly, Véronique
AU - Sung, Patrick
AU - Prakash, Louise
AU - Prakash, Satya
PY - 1995/4/14
Y1 - 1995/4/14
N2 - general transcription factor TFIIH is indispensable for transcription initiation and some of its subunits are known to be required for nucleotide excision repair (NER) of DNA damaged by ultraviolet light. RAD3, a subunit of TFIIH, binds UV-damaged DNA in an ATP-dependent manner. It has, however, remained unclear how TFIIH is assembled with the other damage recognition component RAD14. Here, we demonstrate a higher order complex consisting of TFIIH, RAD14, and another NER protein RAD23, and complex formation between TFIIH and RAD14 is facilitated by the RAD23 protein.
AB - general transcription factor TFIIH is indispensable for transcription initiation and some of its subunits are known to be required for nucleotide excision repair (NER) of DNA damaged by ultraviolet light. RAD3, a subunit of TFIIH, binds UV-damaged DNA in an ATP-dependent manner. It has, however, remained unclear how TFIIH is assembled with the other damage recognition component RAD14. Here, we demonstrate a higher order complex consisting of TFIIH, RAD14, and another NER protein RAD23, and complex formation between TFIIH and RAD14 is facilitated by the RAD23 protein.
UR - https://www.scopus.com/pages/publications/0028916482
UR - https://www.scopus.com/pages/publications/0028916482#tab=citedBy
U2 - 10.1074/jbc.270.15.8385
DO - 10.1074/jbc.270.15.8385
M3 - Article
C2 - 7721729
AN - SCOPUS:0028916482
SN - 0021-9258
VL - 270
SP - 8385
EP - 8388
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 15
ER -