@article{dcc9a6a6870a41ccb5dccf0d8b04d597,
title = "XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages",
abstract = "The phenotypically similar hamster mutants irs1 and irs1SF exhibit high spontaneous chromosome instability and broad-spectrum mutagen sensitivity, including extreme sensitivity to DNA cross-linking agents. The human XRCC2 and XRCC3 genes, which functionally complement irs1 and irs1SF, respectively, were previously mapped in somatic cell hybrids. Characterization of these genes and sequence alignments reveal that XRCC2 and XRCC3 are members of an emerging family of Rad51-related proteins that likely participate in homologous recombination to maintain chromosome stability and repair DNA damage. XRCC3 is shown to interact directly with HsRad51, and like Rad55 and Rad57 in yeast, may cooperate with HsRad51 during recombinational repair. Analysis of the XRCC2 mutation in irs1 implies that XRCC2's function is not essential for viability in cultured hamster cells.",
author = "Nan Liu and Lamerdin, {Jane E.} and Tebbs, {Robert S.} and David Schild and Tucker, {James D.} and Shen, {M. Richard} and Brookman, {Kerry W.} and Siciliano, {Michael J.} and Walter, {Christi A.} and Wufang Fan and Narayana, {Lakshmi S.} and Zhou, {Zi Qiang} and Adamson, {Aaron W.} and Sorensen, {Karen J.} and Chen, {David J.} and Jones, {Nigel J.} and Thompson, {Larry H.}",
note = "Funding Information: We thank Dr. Randy Legerski for the pEBS7 cDNA library and mouse Rad51 antibody, Dr. Rodney Balhorn for providing HsRad51 protein, and Dr. David Wilson for comments on the manuscript. We also thank Lawreen Woo and Stephanie Stilwagen for assistance in purifying and sequencing of P1 and PAC clones and Louis Ramagli for assistance with XRCC2 mapping. This work was done under the auspices of the US Department of Energy by Lawrence Livermore National Laboratory under contract no. W-7405-ENG-48 and Los Alamos National Laboratory under contract no. W-7405-ENG-36, and was also funded by National Institutes of Health grants GM32833, CA34936, CA74046, and GM30990. ",
year = "1998",
month = may,
doi = "10.1016/S1097-2765(00)80078-7",
language = "English (US)",
volume = "1",
pages = "783--793",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "6",
}