@article{0f7c86a150e74f0a84618af2d5275674,
title = "Whole blood microRNA expression associated with stroke: Results from the Framingham Heart Study",
abstract = "Emerging evidence suggests microRNAs (miRNAs) may play an important role in explaining variation in stroke risk and recovery in humans, yet there are still few longitudinal studies examining the association between whole blood miRNAs and stroke. Accounting for multiple testing and adjusting for potentially confounding technical and clinical variables, here we show that whole blood miR-574-3p expression was significantly lower in participants with chronic stroke compared to non-cases. To explore the functional relevance of our findings, we analyzed miRNA-mRNA whole blood co-expression, pathway enrichment, and brain tissue gene expression. Results suggest miR-574-3p is involved in neurometabolic and chronic neuronal injury response pathways, including brain gene expression of DBNDD2 and ELOVL1. These results suggest miR-574-3p plays a role in regulating chronic brain and systemic cellular response to stroke and thus may implicate miR-574-3p as a partial mediator of long-term stroke outcomes.",
author = "Joel Salinas and Honghuang Lin and Aparico, {Hugo J.} and Tianxiao Huan and Chunyu Liu and Jian Rong and Alexa Beiser and Himali, {Jayandra J.} and Freedman, {Jane E.} and Larson, {Martin G.} and Jonathan Rosand and Hermona Soreq and Daniel Levy and Sudha Seshadri",
note = "Funding Information: This research was supported by P30AG10161, R01AG15819, R01AG17917, R01AG30146, R01AG36836, U01AG32984, and U01AG46152 to the Rush Alzheimer{\textquoteright}s Disease Center; N01-HC 25195, HHSN268201500001I, and 75N92019D00031 to the FHS; NS017950, UH2NS100605, AG049505, AG052409, AG054076, AG049607, and AG059421 to SS; T32NS048005, AG057760, and the Robert Katzman Research Training Fellowship in Alzheimer{\textquoteright}s and Dementia Research Cosponsored by the American Academy of Neurology, the American Brain Foundation, and the Alzheimer{\textquoteright}s Association to JS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We are most grateful to the Framingham Heart Study participants who have committed so much of their time and effort. The AMP-AD study data were graciously provided by the Rush Alzheimer{\textquoteright}s Disease Center, Rush University Medical Center, Chicago. Publisher Copyright: {\textcopyright} 2019 Salinas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2019",
month = aug,
day = "1",
doi = "10.1371/journal.pone.0219261",
language = "English (US)",
volume = "14",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",
}