When the Circadian Clock Meets the Melanin Pigmentary System

Andrzej T. Slominski; Rüdiger Hardeland; Russel J. Reiter

doi:10.1038/jid.2014.553

When the Circadian Clock Meets the Melanin Pigmentary System

Andrzej T. Slominski, Rüdiger Hardeland, Russel J. Reiter

Department of Cell Systems & Anatomy

Producción científica: Comment/debate › revisión exhaustiva

19 Citas (Scopus)

Resumen

Silencing of BMAL1 and PER1 stimulates melanogenic activity of follicular and epidermal melanocytes, indicating a novel role for peripheral circadian clock processes in the regulation of melanin pigmentation. Linking the expression levels of BMAL1PER1 with changes in melanogenesis opens exciting opportunities to study the role of the local molecular clock in modulation of melanocyte functions in the hair follicle and the epidermis with attendant effects on epidermal barrier functions in general.

Idioma original	English (US)
Páginas (desde-hasta)	943-945
Número de páginas	3
Publicación	Journal of Investigative Dermatology
Volumen	135
N.º	4
DOI	https://doi.org/10.1038/jid.2014.553
Estado	Published - abr 20 2015

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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abstract = "Silencing of BMAL1 and PER1 stimulates melanogenic activity of follicular and epidermal melanocytes, indicating a novel role for peripheral circadian clock processes in the regulation of melanin pigmentation. Linking the expression levels of BMAL1PER1 with changes in melanogenesis opens exciting opportunities to study the role of the local molecular clock in modulation of melanocyte functions in the hair follicle and the epidermis with attendant effects on epidermal barrier functions in general.",

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AB - Silencing of BMAL1 and PER1 stimulates melanogenic activity of follicular and epidermal melanocytes, indicating a novel role for peripheral circadian clock processes in the regulation of melanin pigmentation. Linking the expression levels of BMAL1PER1 with changes in melanogenesis opens exciting opportunities to study the role of the local molecular clock in modulation of melanocyte functions in the hair follicle and the epidermis with attendant effects on epidermal barrier functions in general.

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When the Circadian Clock Meets the Melanin Pigmentary System

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