Volumetric MRI Differences in Treatment Naïve and Chronically Treated Adolescents With ADHD-Combined Type

Margaret Semrud-Clikeman, Steven R. Pliszka, Jesse Bledsoe, Jack Lancaster

Producción científica: Articlerevisión exhaustiva

23 Citas (Scopus)

Resumen

Objective: The purpose of this study was to determine whether there are differences in the volume of specific brain regions using magnetic resonance imaging (MRI) between children and adolescents with ADHD and controls and whether such differences are related to the participants' history of stimulant treatment. Method: A total of 16 healthy controls, 16 children, and adolescents with ADHD-combined (ADHD-C) type with a history of stimulant treatment, and 13 children and adolescents with ADHD-C type treatment naïve participated. Results: Total frontal, prefrontal, and caudate volumes were larger for children and adolescents with ADHD compared with controls with no differences based on medication history with larger right gray and white matter prefrontal volumes in the ADHD groups. A medication difference was found with the right anterior cingulate cortex smaller in children and adolescents without a treatment history. Conclusion: These findings suggest that aberrant prefrontal and caudate volumes in ADHD-C may compromise functioning of the frontostriatal circuitry.

Idioma originalEnglish (US)
Páginas (desde-hasta)511-520
Número de páginas10
PublicaciónJournal of Attention Disorders
Volumen18
N.º6
DOI
EstadoPublished - ago 2014

ASJC Scopus subject areas

  • Clinical Psychology
  • Developmental and Educational Psychology

Huella

Profundice en los temas de investigación de 'Volumetric MRI Differences in Treatment Naïve and Chronically Treated Adolescents With ADHD-Combined Type'. En conjunto forman una huella única.

Citar esto