Vitamin E: A dark horse at the crossroad of cancer management

Eduardo Cardenas, Rita Ghosh

Producción científica: Comment/debaterevisión exhaustiva

69 Citas (Scopus)

Resumen

It appears that the story on vitamin E and its role in human health remains incomplete. It is apparent that vitamin E supplementation involves many variables, some of which include its uptake from the intestine, the preference for α-tocopherol, transport by tocopherol specific proteins and lipid transporters and the differential metabolism of different vitamin E isoforms. The fundamental differences within population genetics can have significant implications for the effect that dietary supplementation might have on human health. When evaluating the efficacy of vitamin E prophylactic or therapeutic use in previous and future studies, it is critical to consider dosage to be administered, form of vitamin E and source (such as whether from synthetic or purified from natural sources). Further studies are needed to determine the effects of all vitamin E isoforms on cell growth, tumorigenicity, to clarify its possible use as an adjuvant to existing chemotherapeutics. The Alpha-Tocopherol, Beta Carotene (ATBC) Cancer Prevention Study Group and Selenium and Vitamin E Cancer Prevention Trial (SELECT) studies along with the numerous studies of vitamin E should help guide the next chapter of vitamin E research.

Idioma originalEnglish (US)
Páginas (desde-hasta)845-852
Número de páginas8
PublicaciónBiochemical Pharmacology
Volumen86
N.º7
DOI
EstadoPublished - 2013

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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