TY - JOUR
T1 - Viral-associated trichodysplasia in a patient with lymphoma
T2 - A case report and review
AU - Osswald, Sandra S.
AU - Kulick, Kevin B.
AU - Tomaszewski, Maria Magdalena
AU - Sperling, Leonard C.
PY - 2007/9
Y1 - 2007/9
N2 - Viral-associated trichodysplasia is a recently described entity associated with immunosuppression. We describe a 68-year-old man with a history of treated lymphoma who developed numerous, disfiguring, papular and spiny lesions involving most of the central face. Both facial and body alopecia was noted. Histopathologic findings of a facial papule showed dramatic alterations of the hair bulbs, including bulbar distention, lack of hair shaft formation and a marked expansion of inner root sheath type epithelium. These findings were identical to those of previously described cases, so electron microscopy was performed. Numerous intranuclear virus particles were identified. Shortly after the diagnosis of trichodysplasia was made, the patient was found to have a relapse of his lymphoma, which may represent the source of his immunosuppression. Based on his skin biopsy findings, successful antiviral therapy was initiated. This case and a review of previously reported cases are discussed in this study.
AB - Viral-associated trichodysplasia is a recently described entity associated with immunosuppression. We describe a 68-year-old man with a history of treated lymphoma who developed numerous, disfiguring, papular and spiny lesions involving most of the central face. Both facial and body alopecia was noted. Histopathologic findings of a facial papule showed dramatic alterations of the hair bulbs, including bulbar distention, lack of hair shaft formation and a marked expansion of inner root sheath type epithelium. These findings were identical to those of previously described cases, so electron microscopy was performed. Numerous intranuclear virus particles were identified. Shortly after the diagnosis of trichodysplasia was made, the patient was found to have a relapse of his lymphoma, which may represent the source of his immunosuppression. Based on his skin biopsy findings, successful antiviral therapy was initiated. This case and a review of previously reported cases are discussed in this study.
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U2 - 10.1111/j.1600-0560.2006.00693.x
DO - 10.1111/j.1600-0560.2006.00693.x
M3 - Review article
C2 - 17696921
AN - SCOPUS:34547865352
SN - 0303-6987
VL - 34
SP - 721
EP - 725
JO - Journal of Cutaneous Pathology
JF - Journal of Cutaneous Pathology
IS - 9
ER -