Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy

Peter Pytel; Aliya Husain; Ivan Moskowitz; Jai Raman; Heather MacLeod; Allen S. Anderson; Martin Burke; Elizabeth M. McNally

doi:10.1016/j.carpath.2008.09.004

Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy

Peter Pytel
, Aliya Husain
, Ivan Moskowitz
, Jai Raman
, Heather MacLeod
, Allen S. Anderson
, Martin Burke
, Elizabeth M. McNally

Producción científica: Article › revisión exhaustiva

6 Citas (Scopus)

Resumen

A 41-year-old male with cardiomyopathy from an inherited β myosin heavy-chain mutation underwent treatment for heart failure with intramyocardial cell transplantation. He received direct injections into his heart of autologous precursor cells isolated from his blood. He immediately suffered ventricular fibrillation. Although he was resuscitated, he experienced a prolonged downward course that prohibited his undergoing transplantation. His autopsy revealed marked fibrosis throughout the myocardium with areas of mononuclear cell infiltrate. This case highlights the potential adverse effects associated with intramyocardial therapy in the cardiomyopathic heart.

Idioma original	English (US)
Páginas (desde-hasta)	e33-e36
Publicación	Cardiovascular Pathology
Volumen	19
N.º	2
DOI	https://doi.org/10.1016/j.carpath.2008.09.004
Estado	Published - mar 2010
Publicado de forma externa	Sí

ASJC Scopus subject areas

Pathology and Forensic Medicine
Cardiology and Cardiovascular Medicine

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10.1016/j.carpath.2008.09.004

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title = "Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy",

abstract = "A 41-year-old male with cardiomyopathy from an inherited β myosin heavy-chain mutation underwent treatment for heart failure with intramyocardial cell transplantation. He received direct injections into his heart of autologous precursor cells isolated from his blood. He immediately suffered ventricular fibrillation. Although he was resuscitated, he experienced a prolonged downward course that prohibited his undergoing transplantation. His autopsy revealed marked fibrosis throughout the myocardium with areas of mononuclear cell infiltrate. This case highlights the potential adverse effects associated with intramyocardial therapy in the cardiomyopathic heart.",

keywords = "Hypertrophic cardiomyopathy, Intramyocardial cell therapy, Stem cells, Transplant",

author = "Peter Pytel and Aliya Husain and Ivan Moskowitz and Jai Raman and Heather MacLeod and Anderson, \{Allen S.\} and Martin Burke and McNally, \{Elizabeth M.\}",

year = "2010",

month = mar,

doi = "10.1016/j.carpath.2008.09.004",

language = "English (US)",

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TY - JOUR

T1 - Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy

AU - Pytel, Peter

AU - Husain, Aliya

AU - Moskowitz, Ivan

AU - Raman, Jai

AU - MacLeod, Heather

AU - Anderson, Allen S.

AU - Burke, Martin

AU - McNally, Elizabeth M.

PY - 2010/3

Y1 - 2010/3

N2 - A 41-year-old male with cardiomyopathy from an inherited β myosin heavy-chain mutation underwent treatment for heart failure with intramyocardial cell transplantation. He received direct injections into his heart of autologous precursor cells isolated from his blood. He immediately suffered ventricular fibrillation. Although he was resuscitated, he experienced a prolonged downward course that prohibited his undergoing transplantation. His autopsy revealed marked fibrosis throughout the myocardium with areas of mononuclear cell infiltrate. This case highlights the potential adverse effects associated with intramyocardial therapy in the cardiomyopathic heart.

AB - A 41-year-old male with cardiomyopathy from an inherited β myosin heavy-chain mutation underwent treatment for heart failure with intramyocardial cell transplantation. He received direct injections into his heart of autologous precursor cells isolated from his blood. He immediately suffered ventricular fibrillation. Although he was resuscitated, he experienced a prolonged downward course that prohibited his undergoing transplantation. His autopsy revealed marked fibrosis throughout the myocardium with areas of mononuclear cell infiltrate. This case highlights the potential adverse effects associated with intramyocardial therapy in the cardiomyopathic heart.

KW - Hypertrophic cardiomyopathy

KW - Intramyocardial cell therapy

KW - Stem cells

KW - Transplant

UR - https://www.scopus.com/pages/publications/75149122968

UR - https://www.scopus.com/pages/publications/75149122968#tab=citedBy

U2 - 10.1016/j.carpath.2008.09.004

DO - 10.1016/j.carpath.2008.09.004

M3 - Article

C2 - 19026577

AN - SCOPUS:75149122968

SN - 1054-8807

VL - 19

SP - e33-e36

JO - Cardiovascular Pathology

JF - Cardiovascular Pathology

IS - 2

ER -

Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy

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ASJC Scopus subject areas

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