TY - JOUR
T1 - Vasopressin modulates the activity of nicotinic cholinergic mechanisms during memory retrieval in mice
AU - Faiman, Claudia P.
AU - De Erausquin, Gabriel A.
AU - Baratti, Carlos M.
PY - 1988/7
Y1 - 1988/7
N2 - Lysine vasopressin (0.03 μg/kg, sc) enhanced retention test performance on a one-trial step-through inhibitory avoidance task when injected into male Swiss mice 20 min before the retention test. Tests were done 48 h following training. A low dose of the vasopressin antagonist AAVP (0.01 μg/kg, sc, 20 min prior to testing) did not significantly affect retention test performance, whereas a higher dose (0.03 μg/kg, sc) impaired it. Neither lysine vasopressin nor AAVP when given prior to testing modified latencies to step-through of mice that had not received a footshock during training. The simultaneous administration of AAVP (0.01 μg/kg, sc) prevented the enhancement of retention test performance induced by lysine vasopressin. The influence of lysine vasopressin on retention test performance was antagonized by the simultaneous administration of mecamylamine (5 mg/kg, sc) but not by hexamethonium (5 mg/kg, sc), atropine (0.5 mg/kg, sc), or methylatropine (0.5 mg/kg, sc). A modulatory role of vasopressin on the activity of central cholinergic nicotinic mechanisms which probably operate at the time of testing is suggested.
AB - Lysine vasopressin (0.03 μg/kg, sc) enhanced retention test performance on a one-trial step-through inhibitory avoidance task when injected into male Swiss mice 20 min before the retention test. Tests were done 48 h following training. A low dose of the vasopressin antagonist AAVP (0.01 μg/kg, sc, 20 min prior to testing) did not significantly affect retention test performance, whereas a higher dose (0.03 μg/kg, sc) impaired it. Neither lysine vasopressin nor AAVP when given prior to testing modified latencies to step-through of mice that had not received a footshock during training. The simultaneous administration of AAVP (0.01 μg/kg, sc) prevented the enhancement of retention test performance induced by lysine vasopressin. The influence of lysine vasopressin on retention test performance was antagonized by the simultaneous administration of mecamylamine (5 mg/kg, sc) but not by hexamethonium (5 mg/kg, sc), atropine (0.5 mg/kg, sc), or methylatropine (0.5 mg/kg, sc). A modulatory role of vasopressin on the activity of central cholinergic nicotinic mechanisms which probably operate at the time of testing is suggested.
UR - http://www.scopus.com/inward/record.url?scp=0023937324&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023937324&partnerID=8YFLogxK
U2 - 10.1016/S0163-1047(88)90816-3
DO - 10.1016/S0163-1047(88)90816-3
M3 - Article
C2 - 2900001
AN - SCOPUS:0023937324
SN - 0163-1047
VL - 50
SP - 112
EP - 119
JO - Behavioral and Neural Biology
JF - Behavioral and Neural Biology
IS - 1
ER -