Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop

Berislav V. Zlokovic, Rebecca F. Gottesman, Kenneth E. Bernstein, Sudha Seshadri, Ann McKee, Heather Snyder, Steven M. Greenberg, Kristine Yaffe, Chris B. Schaffer, Chun Yuan, Timothy M. Hughes, Mat J. Daemen, Jeff D. Williamson, Hector M. González, Julie Schneider, Cheryl L. Wellington, Zvonimir S. Katusic, Luke Stoeckel, James I. Koenig, Roderick A. CorriveauLawrence Fine, Zorina S. Galis, Jared Reis, Jacqueline D. Wright, Jue Chen

Producción científica: Review articlerevisión exhaustiva

105 Citas (Scopus)

Resumen

Vascular contributions to cognitive impairment and dementia (VCID) are characterized by the aging neurovascular unit being confronted with and failing to cope with biological insults due to systemic and cerebral vascular disease, proteinopathy including Alzheimer's biology, metabolic disease, or immune response, resulting in cognitive decline. This report summarizes the discussion and recommendations from a working group convened by the National Heart, Lung, and Blood Institute and the National Institute of Neurological Disorders and Stroke to evaluate the state of the field in VCID research, identify research priorities, and foster collaborations. As discussed in this report, advances in understanding the biological mechanisms of VCID across the wide spectrum of pathologies, chronic systemic comorbidities, and other risk factors may lead to potential prevention and new treatment strategies to decrease the burden of dementia. Better understanding of the social determinants of health that affect risks for both vascular disease and VCID could provide insight into strategies to reduce racial and ethnic disparities in VCID.

Idioma originalEnglish (US)
Páginas (desde-hasta)1714-1733
Número de páginas20
PublicaciónAlzheimer's and Dementia
Volumen16
N.º12
DOI
EstadoPublished - dic 2020

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Health Policy
  • Developmental Neuroscience
  • Epidemiology

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