TY - JOUR
T1 - Variability of hydroxy-itraconazole in relation to itraconazole bloodstream concentrations
AU - Wiederhold, Nathan P.
AU - Schwartz, Ilan S.
AU - Patterson, Thomas F.
AU - Thompson, George R.
N1 - Publisher Copyright:
Copyright © 2021 American Society for Microbiology. All Rights Reserved.
PY - 2021/4
Y1 - 2021/4
N2 - We analyzed the relationship between itraconazole (ITZ) and hydroxyitraconazole (OH-ITZ) levels in 1,223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (Pearson’s r, 0.7838), and OH-ITZ levels were generally higher than ITZ levels (median OH-ITZ:ITZ ratio, 1.73; range, 0.13 to 8.96). However, marked variability was observed throughout the range of ITZ concentrations. Thus, it is difficult to predict OH-ITZ concentrations based solely on ITZ levels.
AB - We analyzed the relationship between itraconazole (ITZ) and hydroxyitraconazole (OH-ITZ) levels in 1,223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (Pearson’s r, 0.7838), and OH-ITZ levels were generally higher than ITZ levels (median OH-ITZ:ITZ ratio, 1.73; range, 0.13 to 8.96). However, marked variability was observed throughout the range of ITZ concentrations. Thus, it is difficult to predict OH-ITZ concentrations based solely on ITZ levels.
KW - Antifungal efficacy
KW - Bioassay
KW - Bloodstream concentrations
KW - Hydroxy-itraconazole
KW - Itraconazole
KW - TDM
KW - Therapeutic-drug monitoring
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U2 - 10.1128/AAC.02353-20
DO - 10.1128/AAC.02353-20
M3 - Article
C2 - 33468480
AN - SCOPUS:85103037132
SN - 0066-4804
VL - 65
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 4
M1 - e02353-20
ER -