TY - JOUR
T1 - Urorectal septum malformation sequence
AU - Williams IV, Daniel H.
AU - Fitchev, Philip
AU - Policarpio-Nicolas, Maria Luisa C.
AU - Wang, Eileen
AU - Brannigan, Robert E.
AU - Crawford, Susan E.
PY - 2005/9
Y1 - 2005/9
N2 - The urorectal septum malformation sequence consists of absent perineal and anal openings in association with ambiguous genitalia and urogenital, colonic, and lumbosacral anomalies. The full sequence is highly lethal, and the partial sequence, characterized by a single perineal opening draining a common cloaca, is compatible with life. Defects in mesodermal proliferation early in embryogenesis result in this rare condition. Timely urologic and surgical evaluations and reconstructions are imperative and necessary for survival. Urologists should be familiar with the mechanisms and presentations of this condition, as they may be involved in the diagnosis and management of such patients.
AB - The urorectal septum malformation sequence consists of absent perineal and anal openings in association with ambiguous genitalia and urogenital, colonic, and lumbosacral anomalies. The full sequence is highly lethal, and the partial sequence, characterized by a single perineal opening draining a common cloaca, is compatible with life. Defects in mesodermal proliferation early in embryogenesis result in this rare condition. Timely urologic and surgical evaluations and reconstructions are imperative and necessary for survival. Urologists should be familiar with the mechanisms and presentations of this condition, as they may be involved in the diagnosis and management of such patients.
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U2 - 10.1016/j.urology.2005.03.003
DO - 10.1016/j.urology.2005.03.003
M3 - Article
C2 - 16140104
AN - SCOPUS:24144467864
SN - 0090-4295
VL - 66
SP - 657.e5-657.e7
JO - Urology
JF - Urology
IS - 3
ER -