Urinary excretion of retinol in children with acute diarrhea

José O. Alvarez, Eduardo Salazar-Lindo, Jorge Kohatsu, Percy Miranda, Charles B. Stephensen

Producción científica: Articlerevisión exhaustiva

78 Citas (Scopus)

Resumen

Acute infections of childhood are associated with an increased rate of xerophthalmia, apparently due to depletion of vitamin A stores. The mechanism responsible for this is not known. Recently, it has been reported that severe infections in adult patients (ie, sepsis and pneumonia) result in excretion of large quantities of retinol in the urine. In 44 children hospitalized for treatment of acute diarrhea we found mean urinary excretions of 1.44 μmol retinol/24 h on day 1 of hospitalization, 0.62 μmol retinol/24 h on day 2, and 0.23 μmol/24 h on day 3. Healthy control subjects matched for age did not excrete measurable amounts of retinol in the urine. Retinol excretion was associated strongly with rotavirus diarrhea and presence of fever. Furthermore, serum retinol concentration was negatively associated with duration of diarrhea before hospitalization, suggesting that urinary excretion of retinol may be an important contributor to vitamin A depletion.

Idioma originalEnglish (US)
Páginas (desde-hasta)1273-1276
Número de páginas4
PublicaciónAmerican Journal of Clinical Nutrition
Volumen61
N.º6
DOI
EstadoPublished - jun 1995
Publicado de forma externa

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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