Unidirectional migration of osteosarcoma cells with osteoblast characteristics in response to products of bone resorption

Gregory R. Mundy, Sevgi B. Rodan, Robert J. Majeska, Sandra DeMartino, Carol Trimmier, T. John Martin, Gideon A. Rodan

Resultado de la investigación: Articlerevisión exhaustiva

33 Citas (Scopus)

Resumen

To investigate the mechanisms by which bone-forming cells are attracted to areas of bone resorption during bone remodeling, we have used in vitro methods to look for signals released by resorbing bone, which may be chemotactic for cultured bone cells. We have found that cultured rat osteosarcoma cells, which have characteristics associated with the osteoblastic phenotype, migrate in a unidirectional manner in response to a signal released by resorbing bones. These cells also migrated unidirectionally in response to Type I collagen, which comprises 95% of the bone matrix. This phenomenon of chemotaxis of bone-forming cells to sites of previous resorption may be an important component of the process of bone remodeling and the coupling of bone formation to bone resorption.

Idioma originalEnglish (US)
Páginas (desde-hasta)542-546
Número de páginas5
PublicaciónCalcified tissue international
Volumen34
N.º1
DOI
EstadoPublished - dic. 1982

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

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