Understanding the bone/implant interface

B. D. Boyan, V. L. Sylvia, D. D. Dean, C. H. Lohmann, D. L. Cochran, Z. Schwartz

Producción científica: Review articlerevisión exhaustiva

1 Cita (Scopus)


In order to better understand how implant surfaces modulate bone formation, we developed a cell culture model. Cells in the osteoblastic lineage (fetal rat calvarial cells [FRCs]: multipotent osteoprogenitor cells; human osteoblast-like MG63 cells: immature osteoblasts; mouse OCT-1 cells: mature osteoblasts; and mouse MLO-Y4 cells: osteocyte-like cells) were cultured on cpTi disks with either smooth (R(a) = 0.5 μm) or rough (R(a) = 5 μm) surfaces. The effects of surface roughness on proliferation, matrix synthesis, differentiation, local factor production, cell morphology, and response to 1,25-(OH)2D3 were determined. The interaction of surface roughness and surface chemistry in cell response was also examined by culturing MG63 cells on smooth and rough surfaces prepared by machining disks of cpTi or Ti-6Al-4V alloy (Ti-A). The results show that cell differentiation and local factor production are enhanced with increasing surface roughness, whereas proliferation is decreased. Response to 1,25-(OH)2D3 increases with increasing surface roughness. Both surface roughness and 1,25-(OH)2D3 mediate their effects through PGE2, explaining, in part, the synergistic effects of these two variables. While surface chemistry plays a role in determining cell response, surface roughness may be a more important variable with respect to bone formation.

Idioma originalEnglish (US)
Páginas (desde-hasta)123-133
Número de páginas11
EstadoPublished - 1999

ASJC Scopus subject areas

  • General Medicine


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