TY - GEN
T1 - Uncover cooperative gene regulations by microRNAs and transcription factors in glioblastoma using a nonnegative hybrid factor model
AU - Meng, Jia
AU - Chen, Hung I.
AU - Zhang, Jianqiu
AU - Chen, Yidong
AU - Huang, Yufei
PY - 2011
Y1 - 2011
N2 - Transcriptional regulation by transcription factors (TFs) and microRNAs controls when and how much RNA is created. Due to technical limitations, the protein level expressions of TFs are usually unknown, making computational reconstruction of transcriptional network a difficult task. We proposed here a novel Bayesian nonnegative hybrid factor model for transcriptional network modeling, which is capable to estimate both the non-negative abundances of the transcription factors, the regulatory effects of TFs and microRNAs, and the sample clustering information by integrating microarray data and existing knowledge regarding TFs and microRNAs regulated target genes. The results demonstrated its validity and effectiveness to reconstructing transcriptional networks through simulated systems and real data.
AB - Transcriptional regulation by transcription factors (TFs) and microRNAs controls when and how much RNA is created. Due to technical limitations, the protein level expressions of TFs are usually unknown, making computational reconstruction of transcriptional network a difficult task. We proposed here a novel Bayesian nonnegative hybrid factor model for transcriptional network modeling, which is capable to estimate both the non-negative abundances of the transcription factors, the regulatory effects of TFs and microRNAs, and the sample clustering information by integrating microarray data and existing knowledge regarding TFs and microRNAs regulated target genes. The results demonstrated its validity and effectiveness to reconstructing transcriptional networks through simulated systems and real data.
UR - http://www.scopus.com/inward/record.url?scp=80051657837&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051657837&partnerID=8YFLogxK
U2 - 10.1109/ICASSP.2011.5947732
DO - 10.1109/ICASSP.2011.5947732
M3 - Conference contribution
AN - SCOPUS:80051657837
SN - 9781457705397
T3 - ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings
SP - 6012
EP - 6015
BT - 2011 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2011 - Proceedings
T2 - 36th IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2011
Y2 - 22 May 2011 through 27 May 2011
ER -