Tyrosine hydroxylase activity in peripherally denervated rat pineal gland

Guadalberto Hernández, Aixa R. Bello, Ignacio López-Coviella, Pedro Abreu, Natalia Fajardo, Russel J. Reiter, Alexis Hernández, Rafael Alonso

Producción científica: Articlerevisión exhaustiva

8 Citas (Scopus)


The presence of tyrosine hydroxylase (TH) in the rat pineal gland was studied using a combination of immunochemical and biochemical methods. In superior cervical ganglionectomized (SCGx) animals and in isolated pineals incubated for 72 h, both TH immunoreactive (TH-IR) fibers and TH biochemical activity were still present but reduced. Conversely, in dispersed pinealocytes incubated for only 24 h we were unable to detect either TH activity or TH-positive cells. Since in the pineal gland of intact rats total 3-methoxy-4-hydroxy phenylglycol (MHPG) was undetectable, and only traces of norepinephrine (NE) were present in the pineal of ganglionectomized animals, the results suggest a central pinealopetal catecholaminergic pathway which could use dopamine as a neurotransmitter.

Idioma originalEnglish (US)
Páginas (desde-hasta)131-134
Número de páginas4
PublicaciónNeuroscience Letters
EstadoPublished - ago 15 1994
Publicado de forma externa

ASJC Scopus subject areas

  • Neuroscience(all)


Profundice en los temas de investigación de 'Tyrosine hydroxylase activity in peripherally denervated rat pineal gland'. En conjunto forman una huella única.

Citar esto