Type I IFN Sensing by cDCs and CD4+ T Cell Help Are Both Requisite for Cross-Priming of AAV Capsid-Specific CD8+ T Cells

Jamie L. Shirley; Geoffrey D. Keeler; Alexandra Sherman; Irene Zolotukhin; David M. Markusic; Brad E. Hoffman; Laurence M. Morel; Mark A. Wallet; Cox Terhorst; Roland W. Herzog

doi:10.1016/j.ymthe.2019.11.011

Type I IFN Sensing by cDCs and CD4⁺ T Cell Help Are Both Requisite for Cross-Priming of AAV Capsid-Specific CD8⁺ T Cells

Jamie L. Shirley
, Geoffrey D. Keeler
, Alexandra Sherman
, Irene Zolotukhin
, David M. Markusic
, Brad E. Hoffman
, Laurence M. Morel
, Mark A. Wallet
, Cox Terhorst
, Roland W. Herzog

Producción científica: Article › revisión exhaustiva

63 Citas (Scopus)

Resumen

Immune responses complicate the use of adeno-associated virus (AAV) vectors in human gene therapy. Shirley et al. define a mechanism by which cross-presentation of viral capsid results in activation of CD8⁺ T cells, which involves sensing of IFN I by conventional dendritic cells and co-stimulation by CD4⁺ T helper cells.

Idioma original	English (US)
Páginas (desde-hasta)	758-770
Número de páginas	13
Publicación	Molecular Therapy
Volumen	28
N.º	3
DOI	https://doi.org/10.1016/j.ymthe.2019.11.011
Estado	Published - mar 4 2020
Publicado de forma externa	Sí

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Pharmacology
Drug Discovery

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10.1016/j.ymthe.2019.11.011

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title = "Type I IFN Sensing by cDCs and CD4+ T Cell Help Are Both Requisite for Cross-Priming of AAV Capsid-Specific CD8+ T Cells",

abstract = "Immune responses complicate the use of adeno-associated virus (AAV) vectors in human gene therapy. Shirley et al. define a mechanism by which cross-presentation of viral capsid results in activation of CD8+ T cells, which involves sensing of IFN I by conventional dendritic cells and co-stimulation by CD4+ T helper cells.",

keywords = "CD8 T cell, adeno-associated virus, dendritic cell, innate immunity, type I interferon",

author = "Shirley, \{Jamie L.\} and Keeler, \{Geoffrey D.\} and Alexandra Sherman and Irene Zolotukhin and Markusic, \{David M.\} and Hoffman, \{Brad E.\} and Morel, \{Laurence M.\} and Wallet, \{Mark A.\} and Cox Terhorst and Herzog, \{Roland W.\}",

note = "Publisher Copyright: {\textcopyright} 2019 The American Society of Gene and Cell Therapy",

year = "2020",

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doi = "10.1016/j.ymthe.2019.11.011",

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AU - Shirley, Jamie L.

AU - Keeler, Geoffrey D.

AU - Sherman, Alexandra

AU - Zolotukhin, Irene

AU - Markusic, David M.

AU - Hoffman, Brad E.

AU - Morel, Laurence M.

AU - Wallet, Mark A.

AU - Terhorst, Cox

AU - Herzog, Roland W.

PY - 2020/3/4

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AB - Immune responses complicate the use of adeno-associated virus (AAV) vectors in human gene therapy. Shirley et al. define a mechanism by which cross-presentation of viral capsid results in activation of CD8+ T cells, which involves sensing of IFN I by conventional dendritic cells and co-stimulation by CD4+ T helper cells.

KW - CD8 T cell

KW - adeno-associated virus

KW - dendritic cell

KW - innate immunity

KW - type I interferon

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