TY - JOUR
T1 - Type 2 Diabetes Independent of Glycemic Control is Associated With Cognitive Impairments
T2 - Findings From NHANES
AU - Jiwani, Rozmin
AU - Dennis, Brittany
AU - Neri, Alfonso L.
AU - Bess, Chandler
AU - Espinoza, Sara
AU - Wang, Jing
AU - Serra, Monica C.
N1 - Publisher Copyright:
© The Author(s) 2022.
PY - 2022/9
Y1 - 2022/9
N2 - Examine the association between glycemic control and cognition. Included subjects ≥60 years who participated in the 2013 to 2014 National Health and Nutrition Examination Survey and completed one of the followings: Consortium to Establish a Registry for Alzheimer’s Disease Word List (CERAD-WL), Animal Fluency (AF), Digit Symbol Substitution Test (DSST), and CERAD-Delayed Recall (CERAD-DR). Stratified participants into: No type 2 diabetes (T2D; N = 557), Controlled T2D (N = 41), Uncontrolled T2D (N = 120), and Untreated T2D (N = 86). Multiple regression was used to examine the association between variables. After adjusting for demographics and cardiovascular risk factors, Uncontrolled T2D was associated with lower DSST (β = −3.164, p =.04), and Untreated T2D was associated with a trend for having lower CERAD-DR (β = −.496, p =.06) scores. T2D, independent of glycemic control, is associated with cognitive impairment and this relationship is influenced by modifiable and non-modifiable risk factors.
AB - Examine the association between glycemic control and cognition. Included subjects ≥60 years who participated in the 2013 to 2014 National Health and Nutrition Examination Survey and completed one of the followings: Consortium to Establish a Registry for Alzheimer’s Disease Word List (CERAD-WL), Animal Fluency (AF), Digit Symbol Substitution Test (DSST), and CERAD-Delayed Recall (CERAD-DR). Stratified participants into: No type 2 diabetes (T2D; N = 557), Controlled T2D (N = 41), Uncontrolled T2D (N = 120), and Untreated T2D (N = 86). Multiple regression was used to examine the association between variables. After adjusting for demographics and cardiovascular risk factors, Uncontrolled T2D was associated with lower DSST (β = −3.164, p =.04), and Untreated T2D was associated with a trend for having lower CERAD-DR (β = −.496, p =.06) scores. T2D, independent of glycemic control, is associated with cognitive impairment and this relationship is influenced by modifiable and non-modifiable risk factors.
KW - NHANES
KW - Type 2 diabetes
KW - cardiovascular risk factors
KW - cognition
KW - glycemic control
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U2 - 10.1177/10547738221100344
DO - 10.1177/10547738221100344
M3 - Article
C2 - 35614549
AN - SCOPUS:85131057805
SN - 1054-7738
VL - 31
SP - 1225
EP - 1233
JO - Clinical Nursing Research
JF - Clinical Nursing Research
IS - 7
ER -