Trisnorsqualene methyl hydroxylamine: a potent dual inhibitor of mammalian squalene epoxidase and oxidosqualene cyclase

Gregory M. Anstead; Hung Kuei Lin; Glenn D. Prestwich

doi:10.1016/S0960-894X(00)80339-X

Trisnorsqualene methyl hydroxylamine: a potent dual inhibitor of mammalian squalene epoxidase and oxidosqualene cyclase

Gregory M. Anstead, Hung Kuei Lin, Glenn D. Prestwich

Producción científica: Article › revisión exhaustiva

7 Citas (Scopus)

Resumen

Squalene epoxidase and oxidosqualene cyclase, two sequential enzymes in the sterol biosynthesis pathway, are inhibited effectively by trisnorsqualene methyl hydroxylamine.

Idioma original	English (US)
Páginas (desde-hasta)	1319-1322
Número de páginas	4
Publicación	Bioorganic and Medicinal Chemistry Letters
Volumen	3
N.º	6
DOI	https://doi.org/10.1016/S0960-894X(00)80339-X
Estado	Published - jun 1993
Publicado de forma externa	Sí

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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title = "Trisnorsqualene methyl hydroxylamine: a potent dual inhibitor of mammalian squalene epoxidase and oxidosqualene cyclase",

abstract = "Squalene epoxidase and oxidosqualene cyclase, two sequential enzymes in the sterol biosynthesis pathway, are inhibited effectively by trisnorsqualene methyl hydroxylamine.",

author = "Anstead, {Gregory M.} and Lin, {Hung Kuei} and Prestwich, {Glenn D.}",

year = "1993",

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T1 - Trisnorsqualene methyl hydroxylamine

T2 - a potent dual inhibitor of mammalian squalene epoxidase and oxidosqualene cyclase

AU - Anstead, Gregory M.

AU - Lin, Hung Kuei

AU - Prestwich, Glenn D.

PY - 1993/6

Y1 - 1993/6

N2 - Squalene epoxidase and oxidosqualene cyclase, two sequential enzymes in the sterol biosynthesis pathway, are inhibited effectively by trisnorsqualene methyl hydroxylamine.

AB - Squalene epoxidase and oxidosqualene cyclase, two sequential enzymes in the sterol biosynthesis pathway, are inhibited effectively by trisnorsqualene methyl hydroxylamine.

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U2 - 10.1016/S0960-894X(00)80339-X

DO - 10.1016/S0960-894X(00)80339-X

M3 - Article

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IS - 6

ER -

Trisnorsqualene methyl hydroxylamine: a potent dual inhibitor of mammalian squalene epoxidase and oxidosqualene cyclase

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