Triple viral retinitis diagnosed by polymerase chain reaction of the vitreous biopsy in a patient with Richter syndrome

Ralph D. Levinson; John J. Hooks; Yun Wang; Mark T. Chiu; Judianne Kellaway; Chi Chao Chan

doi:10.1016/S0002-9394(98)00138-X

Triple viral retinitis diagnosed by polymerase chain reaction of the vitreous biopsy in a patient with Richter syndrome

Ralph D. Levinson, John J. Hooks, Yun Wang, Mark T. Chiu, Judianne Kellaway, Chi Chao Chan

Producción científica: Article › revisión exhaustiva

8 Citas (Scopus)

Resumen

PURPOSE: To report the evaluation and identification of herpes viruses associated with retinitis in a patient with Richter syndrome. METHODS: Diagnostic vitrectomy was performed on a patient with systemic leukemia and retinitis. The vitreous sample was evaluated by cytology, analysis of cytokines by ELISA, and detection of virus by polymerase chain reaction. RESULTS: The vitreous biopsy specimen showed no malignant cells but predominant CD8⁺ lymphocyte infiltration with elevated interferon gamma and interleukin-6. DNA amplification and Southern blot analysis demonstrated DNA of herpes simplex, varicella-zoster, and cytomegalovirus. CONCLUSION: Retinitis associated with multiple viruses in the vitreous biopsy may mimic leukemic infiltration in the eye.

Idioma original	English (US)
Páginas (desde-hasta)	732-733
Número de páginas	2
Publicación	American journal of ophthalmology
Volumen	126
N.º	5
DOI	https://doi.org/10.1016/S0002-9394(98)00138-X
Estado	Published - nov 1998
Publicado de forma externa	Sí

ASJC Scopus subject areas

Ophthalmology

Acceder al documento

10.1016/S0002-9394(98)00138-X

Otros archivos y enlaces

Citar esto

@article{c7b399f6cda84a369d51ad019150f716,

title = "Triple viral retinitis diagnosed by polymerase chain reaction of the vitreous biopsy in a patient with Richter syndrome",

abstract = "PURPOSE: To report the evaluation and identification of herpes viruses associated with retinitis in a patient with Richter syndrome. METHODS: Diagnostic vitrectomy was performed on a patient with systemic leukemia and retinitis. The vitreous sample was evaluated by cytology, analysis of cytokines by ELISA, and detection of virus by polymerase chain reaction. RESULTS: The vitreous biopsy specimen showed no malignant cells but predominant CD8+ lymphocyte infiltration with elevated interferon gamma and interleukin-6. DNA amplification and Southern blot analysis demonstrated DNA of herpes simplex, varicella-zoster, and cytomegalovirus. CONCLUSION: Retinitis associated with multiple viruses in the vitreous biopsy may mimic leukemic infiltration in the eye.",

author = "Levinson, {Ralph D.} and Hooks, {John J.} and Yun Wang and Chiu, {Mark T.} and Judianne Kellaway and Chan, {Chi Chao}",

year = "1998",

month = nov,

doi = "10.1016/S0002-9394(98)00138-X",

language = "English (US)",

volume = "126",

pages = "732--733",

journal = "American journal of ophthalmology",

issn = "0002-9394",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Triple viral retinitis diagnosed by polymerase chain reaction of the vitreous biopsy in a patient with Richter syndrome

AU - Levinson, Ralph D.

AU - Hooks, John J.

AU - Wang, Yun

AU - Chiu, Mark T.

AU - Kellaway, Judianne

AU - Chan, Chi Chao

PY - 1998/11

Y1 - 1998/11

N2 - PURPOSE: To report the evaluation and identification of herpes viruses associated with retinitis in a patient with Richter syndrome. METHODS: Diagnostic vitrectomy was performed on a patient with systemic leukemia and retinitis. The vitreous sample was evaluated by cytology, analysis of cytokines by ELISA, and detection of virus by polymerase chain reaction. RESULTS: The vitreous biopsy specimen showed no malignant cells but predominant CD8+ lymphocyte infiltration with elevated interferon gamma and interleukin-6. DNA amplification and Southern blot analysis demonstrated DNA of herpes simplex, varicella-zoster, and cytomegalovirus. CONCLUSION: Retinitis associated with multiple viruses in the vitreous biopsy may mimic leukemic infiltration in the eye.

AB - PURPOSE: To report the evaluation and identification of herpes viruses associated with retinitis in a patient with Richter syndrome. METHODS: Diagnostic vitrectomy was performed on a patient with systemic leukemia and retinitis. The vitreous sample was evaluated by cytology, analysis of cytokines by ELISA, and detection of virus by polymerase chain reaction. RESULTS: The vitreous biopsy specimen showed no malignant cells but predominant CD8+ lymphocyte infiltration with elevated interferon gamma and interleukin-6. DNA amplification and Southern blot analysis demonstrated DNA of herpes simplex, varicella-zoster, and cytomegalovirus. CONCLUSION: Retinitis associated with multiple viruses in the vitreous biopsy may mimic leukemic infiltration in the eye.

UR - http://www.scopus.com/inward/record.url?scp=0032213663&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032213663&partnerID=8YFLogxK

U2 - 10.1016/S0002-9394(98)00138-X

DO - 10.1016/S0002-9394(98)00138-X

M3 - Article

C2 - 9822244

AN - SCOPUS:0032213663

SN - 0002-9394

VL - 126

SP - 732

EP - 733

JO - American journal of ophthalmology

JF - American journal of ophthalmology

IS - 5

ER -

Triple viral retinitis diagnosed by polymerase chain reaction of the vitreous biopsy in a patient with Richter syndrome

Resumen

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto