TY - JOUR
T1 - TRANSPLANTATION FOR ACUTE LEUKAEMIA WITH HLA-A AND B NONIDENTICAL PARENTAL MARROW CELLS FRACTIONATED WITH SOYBEAN AGGLUTININ AND SHEEP RED BLOOD CELLS
AU - Reisner, Yair
AU - Kirkpatrick, Dahlia
AU - Dupont, Bo
AU - Kapoor, Neena
AU - Pollack, Marilyn S.
AU - Good, Robert A.
AU - O'Reilly, Richard J.
N1 - Funding Information:
This investigation was supported by National Institutes of Health grants: CA-08748, CA-23766, CA-22507, AI-11843, NA-11457; by the Siegfried and Josephine Bieber Foundation, the Jeanne and Robert Rimsky Cellular Engineering Fund, the George Fredrick Jewett Foundation, the Mazer Fellowship of the Israeli Scholars Exchange Program, the New Hope Chapter in Memory of Francis Kencht, the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation, the Charles A. Dana Foundation, the Judith Harris Selig Memorial Fund, the Arthur Vining Davis Foundation, and the Zelda Radow Weintraub Cancer Fund.
PY - 1981/8/15
Y1 - 1981/8/15
N2 - A new procedure for enrichment of marrow precursors and removal of T lymphocytes from large volumes of human bone marrow, involving initial differential agglutination of T lymphocytes and mature marrow elements with soybean agglutinin, followed by rosetting with sheep red blood cells, was used to fractionate marrow cells from an HLA-A, B, DR non-identical, MLC non-reactive, paternal donor for transplantation into an infant with acute leukaemia. This transplant became completely engrafted and resulted in full recovery of normal, donor-derived haematopoietic function without graft-versus-host disease, sustained for 11 weeks after transplantation, at-which time the patient's leukaemia recurred. Subsequently, the patient received chemotherapy and achieved a remission with regeneration of normal marrow cells of donor origin. The patient's course demonstrated the potential of lectin separated marrow grafts to restore durable haematopoiesis, without graft-versus-host disease, in a lethally irradiated allogeneic host.
AB - A new procedure for enrichment of marrow precursors and removal of T lymphocytes from large volumes of human bone marrow, involving initial differential agglutination of T lymphocytes and mature marrow elements with soybean agglutinin, followed by rosetting with sheep red blood cells, was used to fractionate marrow cells from an HLA-A, B, DR non-identical, MLC non-reactive, paternal donor for transplantation into an infant with acute leukaemia. This transplant became completely engrafted and resulted in full recovery of normal, donor-derived haematopoietic function without graft-versus-host disease, sustained for 11 weeks after transplantation, at-which time the patient's leukaemia recurred. Subsequently, the patient received chemotherapy and achieved a remission with regeneration of normal marrow cells of donor origin. The patient's course demonstrated the potential of lectin separated marrow grafts to restore durable haematopoiesis, without graft-versus-host disease, in a lethally irradiated allogeneic host.
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U2 - 10.1016/S0140-6736(81)90647-4
DO - 10.1016/S0140-6736(81)90647-4
M3 - Article
C2 - 6115110
AN - SCOPUS:0019390679
VL - 318
SP - 327
EP - 331
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 8242
ER -