TRANSPLANTATION FOR ACUTE LEUKAEMIA WITH HLA-A AND B NONIDENTICAL PARENTAL MARROW CELLS FRACTIONATED WITH SOYBEAN AGGLUTININ AND SHEEP RED BLOOD CELLS

Yair Reisner, Dahlia Kirkpatrick, Bo Dupont, Neena Kapoor, Marilyn S. Pollack, Robert A. Good, Richard J. O'Reilly

Resultado de la investigación: Articlerevisión exhaustiva

291 Citas (Scopus)

Resumen

A new procedure for enrichment of marrow precursors and removal of T lymphocytes from large volumes of human bone marrow, involving initial differential agglutination of T lymphocytes and mature marrow elements with soybean agglutinin, followed by rosetting with sheep red blood cells, was used to fractionate marrow cells from an HLA-A, B, DR non-identical, MLC non-reactive, paternal donor for transplantation into an infant with acute leukaemia. This transplant became completely engrafted and resulted in full recovery of normal, donor-derived haematopoietic function without graft-versus-host disease, sustained for 11 weeks after transplantation, at-which time the patient's leukaemia recurred. Subsequently, the patient received chemotherapy and achieved a remission with regeneration of normal marrow cells of donor origin. The patient's course demonstrated the potential of lectin separated marrow grafts to restore durable haematopoiesis, without graft-versus-host disease, in a lethally irradiated allogeneic host.

Idioma originalEnglish (US)
Páginas (desde-hasta)327-331
Número de páginas5
PublicaciónThe Lancet
Volumen318
N.º8242
DOI
EstadoPublished - ago. 15 1981
Publicado de forma externa

ASJC Scopus subject areas

  • Medicine(all)

Huella

Profundice en los temas de investigación de 'TRANSPLANTATION FOR ACUTE LEUKAEMIA WITH HLA-A AND B NONIDENTICAL PARENTAL MARROW CELLS FRACTIONATED WITH SOYBEAN AGGLUTININ AND SHEEP RED BLOOD CELLS'. En conjunto forman una huella única.

Citar esto