Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation

Jemma Victoria Walker; Heng Zhuang; Donald Singer; Charlotte Sara Illsley; Wai Ling Kok; Kishor K. Sivaraj; Yan Gao; Chloe Bolton; Yuying Liu; Mengyuan Zhao; Portia Rebecca Clare Grayson; Shuang Wang; Jana Karbanová; Tim Lee; Stefano Ardu; Qingguo Lai; Jihui Liu; Moustapha Kassem; Shuo Chen; Kai Yang; Yuxing Bai; Christopher Tredwin; Alexander C. Zambon; Denis Corbeil; Ralf Adams; Basem M. Abdallah; Bing Hu

doi:10.1038/s41467-019-11611-0

Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation

Jemma Victoria Walker, Heng Zhuang, Donald Singer, Charlotte Sara Illsley, Wai Ling Kok, Kishor K. Sivaraj, Yan Gao, Chloe Bolton, Yuying Liu, Mengyuan Zhao, Portia Rebecca Clare Grayson, Shuang Wang, Jana Karbanová, Tim Lee, Stefano Ardu, Qingguo Lai, Jihui Liu, Moustapha Kassem, Shuo Chen, Kai YangYuxing Bai, Christopher Tredwin, Alexander C. Zambon, Denis Corbeil, Ralf Adams, Basem M. Abdallah, Bing Hu

Department of Developmental Dentistry

Producción científica: Article › revisión exhaustiva

35 Citas (Scopus)

Resumen

Stem cells (SCs) receive inductive cues from the surrounding microenvironment and cells. Limited molecular evidence has connected tissue-specific mesenchymal stem cells (MSCs) with mesenchymal transit amplifying cells (MTACs). Using mouse incisor as the model, we discover a population of MSCs neibouring to the MTACs and epithelial SCs. With Notch signaling as the key regulator, we disclose molecular proof and lineage tracing evidence showing the distinct MSCs contribute to incisor MTACs and the other mesenchymal cell lineages. MTACs can feedback and regulate the homeostasis and activation of CL-MSCs through Delta-like 1 homolog (Dlk1), which balances MSCs-MTACs number and the lineage differentiation. Dlk1’s function on SCs priming and self-renewal depends on its biological forms and its gene expression is under dynamic epigenetic control. Our findings can be validated in clinical samples and applied to accelerate tooth wound healing, providing an intriguing insight of how to direct SCs towards tissue regeneration.

Idioma original	English (US)
Número de artículo	3596
Publicación	Nature communications
Volumen	10
N.º	1
DOI	https://doi.org/10.1038/s41467-019-11611-0
Estado	Published - dic 1 2019

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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10.1038/s41467-019-11611-0

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Walker, J. V., Zhuang, H., Singer, D., Illsley, C. S., Kok, W. L., Sivaraj, K. K., Gao, Y., Bolton, C., Liu, Y., Zhao, M., Grayson, P. R. C., Wang, S., Karbanová, J., Lee, T., Ardu, S., Lai, Q., Liu, J., Kassem, M., Chen, S., ... Hu, B. (2019). Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation. Nature communications, 10(1), Artículo 3596. https://doi.org/10.1038/s41467-019-11611-0

Walker, JV, Zhuang, H, Singer, D, Illsley, CS, Kok, WL, Sivaraj, KK, Gao, Y, Bolton, C, Liu, Y, Zhao, M, Grayson, PRC, Wang, S, Karbanová, J, Lee, T, Ardu, S, Lai, Q, Liu, J, Kassem, M, Chen, S, Yang, K, Bai, Y, Tredwin, C, Zambon, AC, Corbeil, D, Adams, R, Abdallah, BM & Hu, B 2019, 'Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation', Nature communications, vol. 10, n.º 1, 3596. https://doi.org/10.1038/s41467-019-11611-0

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title = "Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation",

abstract = "Stem cells (SCs) receive inductive cues from the surrounding microenvironment and cells. Limited molecular evidence has connected tissue-specific mesenchymal stem cells (MSCs) with mesenchymal transit amplifying cells (MTACs). Using mouse incisor as the model, we discover a population of MSCs neibouring to the MTACs and epithelial SCs. With Notch signaling as the key regulator, we disclose molecular proof and lineage tracing evidence showing the distinct MSCs contribute to incisor MTACs and the other mesenchymal cell lineages. MTACs can feedback and regulate the homeostasis and activation of CL-MSCs through Delta-like 1 homolog (Dlk1), which balances MSCs-MTACs number and the lineage differentiation. Dlk1{\textquoteright}s function on SCs priming and self-renewal depends on its biological forms and its gene expression is under dynamic epigenetic control. Our findings can be validated in clinical samples and applied to accelerate tooth wound healing, providing an intriguing insight of how to direct SCs towards tissue regeneration.",

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AU - Walker, Jemma Victoria

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AU - Illsley, Charlotte Sara

AU - Kok, Wai Ling

AU - Sivaraj, Kishor K.

AU - Gao, Yan

AU - Bolton, Chloe

AU - Liu, Yuying

AU - Zhao, Mengyuan

AU - Grayson, Portia Rebecca Clare

AU - Wang, Shuang

AU - Karbanová, Jana

AU - Lee, Tim

AU - Ardu, Stefano

AU - Lai, Qingguo

AU - Liu, Jihui

AU - Kassem, Moustapha

AU - Chen, Shuo

AU - Yang, Kai

AU - Bai, Yuxing

AU - Tredwin, Christopher

AU - Zambon, Alexander C.

AU - Corbeil, Denis

AU - Adams, Ralf

AU - Abdallah, Basem M.

AU - Hu, Bing

PY - 2019/12/1

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Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation

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ASJC Scopus subject areas

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