Transient hepatic response to glucagon in man: Role of insulin and hyperglycemia

E. Ferrannini, R. A. DeFronzo, R. S. Sherwin

Resultado de la investigación: Articlerevisión exhaustiva

48 Citas (Scopus)


We infused glucagon into normal humans with preventing changes in plasma glucose and insulin. Insulin (0.45 was infused for 90 min, while euglycemia was maintained by a variable glucose infusion. Subsequently, glucagon (6 was added, and changes in plasma glycose were avoided by appropriately reducing the glucose infusion. With insulin alone, glucose production (GP) fell to zero. When hyperglucagonemia (530 ± 32 was superimposed, GP rose promptly and then slowly declined. However, between 180 and 240 min, GP remained elevated (1.72 ± 0.30 as compard to an insulin control study (0.03 ± 0.20, P < 0.025). When hyperglycemia (+25 mg/100 ml) was induced between 180 and 240 min, glucagon-stimulated GP was completely suppressed. To determine whether this effect was mediated by hyperglycemia per se or glucose-induced hyperinsulinemia, between 180 and 240 min we increased either a) the insulin infusion (by 0.25 while maintaining euglycemia or b) plasma glucose (+25 mg/100 ml) while blocking insulin release with somatostatin. When the insulin was increased, GP declined by 68 ± 13% (P < 0.02). When plasma glucose alone was raised, GP fell from 1.44 ± 0.09 to 0.07 ± 0.16 (< 0.002). In conclusion, the hepatic response to sustained hyperglucagonemia is more persistent if changes in plasma glucose are prevented, and its transient nature is in part explained by a feedback adjustment to glucagon-induced hyperglycemia and hyperinsulinemia.

Idioma originalEnglish (US)
Páginas (desde-hasta)E73-E81
PublicaciónAmerican Journal of Physiology - Endocrinology and Metabolism
EstadoPublished - ene 1 1982
Publicado de forma externa

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)


Profundice en los temas de investigación de 'Transient hepatic response to glucagon in man: Role of insulin and hyperglycemia'. En conjunto forman una huella única.

Citar esto