Transcriptomics in type 2 diabetes: Bridging the gap between genotype and phenotype

Christopher P. Jenkinson, Harald H.H. Göring, Rector Arya, John Blangero, Ravindranath Duggirala, Ralph A. DeFronzo

Resultado de la investigación: Articlerevisión exhaustiva

27 Citas (Scopus)

Resumen

Type 2 diabetes (T2D) is a common, multifactorial disease that is influenced by genetic and environmental factors and their interactions. However, common variants identified by genome wide association studies (GWAS) explain only about 10% of the total trait variance for T2D and less than 5% of the variance for obesity, indicating that a large proportion of heritability is still unexplained. The transcriptomic approach described here uses quantitative gene expression and disease-related physiological data (deep phenotyping) to measure the direct correlation between the expression of specific genes and physiological traits. Transcriptomic analysis bridges the gulf between GWAS and physiological studies. Recent GWAS studies have utilized very large population samples, numbering in the tens of thousands (or even hundreds of thousands) of individuals, yet establishing causal functional relationships between strongly associated genetic variants and disease remains elusive. In light of the findings described below, it is appropriate to consider how and why transcriptomic approaches in small samples might be capable of identifying complex disease-related genes which are not apparent using GWAS in large samples.

Idioma originalEnglish (US)
Páginas (desde-hasta)25-36
Número de páginas12
PublicaciónGenomics Data
Volumen8
DOI
EstadoPublished - jun 1 2016

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Medicine
  • Genetics

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