Transcriptional control of ILC identity

Producción científica: Review articlerevisión exhaustiva

1 Cita (Scopus)


Innate lymphoid cells (ILCs) are heterogeneous innate immune cells which participate in host defense, mucosal repair and immunopathology by producing effector cytokines similarly to their adaptive immune cell counterparts. The development of ILC1, 2, and 3 subsets is controlled by core transcription factors: T-bet, GATA3, and RORγt, respectively. ILCs can undergo plasticity and transdifferentiate to other ILC subsets in response to invading pathogens and changes in local tissue environment. Accumulating evidence suggests that the plasticity and the maintenance of ILC identity is controlled by a balance between these and additional transcription factors such as STATs, Batf, Ikaros, Runx3, c-Maf, Bcl11b, and Zbtb46, activated in response to lineage-guiding cytokines. However, how interplay between these transcription factors leads to ILC plasticity and the maintenance of ILC identity remains hypothetical. In this review, we discuss recent advances in understanding transcriptional regulation of ILCs in homeostatic and inflammatory conditions.

Idioma originalEnglish (US)
Número de artículo1146077
PublicaciónFrontiers in immunology
EstadoPublished - 2023

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Profundice en los temas de investigación de 'Transcriptional control of ILC identity'. En conjunto forman una huella única.

Citar esto