Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex

Tabish Hussain, Dhurjhoti Saha, Gunjan Purohit, Anirban Kar, Anand Kishore Mukherjee, Shalu Sharma, Suman Sengupta, Parashar Dhapola, Basudeb Maji, Sreekanth Vedagopuram, Nobuko T. Horikoshi, Nobuo Horikoshi, Raj K. Pandita, Santanu Bhattacharya, Avinash Bajaj, Jean François Riou, Tej K. Pandita, Shantanu Chowdhury

Producción científica: Articlerevisión exhaustiva

41 Citas (Scopus)

Resumen

We observed extra-telomeric binding of the telomere repeat binding factor TRF2 within the promoter of the cyclin-dependent kinase CDKNIA (p21/CIP1/WAF1). This result in TRF2 induced transcription repression of p21. Interestingly, p21 repression was through engagement of the REST-coREST-LSD1-repressor complex and altered histone marks at the p21 promoter in a TRF2-dependent fashion. Furthermore, mutational analysis shows p21 repression requires interaction of TRF2 with a p21 promoter G-quadruplex. Physiologically, TRF2-mediated p21 repression attenuated drug-induced activation of cellular DNA damage response by evading G2/M arrest in cancer cells. Together these reveal for the first time role of TRF2 in REST-repressor complex mediated transcription repression.

Idioma originalEnglish (US)
Número de artículo11541
PublicaciónScientific reports
Volumen7
N.º1
DOI
EstadoPublished - dic 1 2017
Publicado de forma externa

ASJC Scopus subject areas

  • General

Huella

Profundice en los temas de investigación de 'Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex'. En conjunto forman una huella única.

Citar esto