Transcription association of VHL and SDH mutations link hypoxia and oxidoreductase signals in pheochromocytomas

Producción científica: Conference contribution

39 Citas (Scopus)


Pheochromocytomas and paragangliomas are neural-crest-derived tumors that arise from mutations in RET, VHL, NF1, and in the genes-encoding succinate dehydrogenase (SDH) subunits B (SDHB), C (SDHC), and D (SDHD). Despite their genetic diversity, these tumors cannot be clearly distinguished on the basis of their primary mutation. We recently identified two major transcriptional programs embedded within familial and sporadic pheochromocytomas and paragangliomas using global expression profiling. This review will summarize the major results of these studies and discuss their implications. The transcription data revealed that: (a) tumors with mutations in VHL, SDHB, and SDHD genes share a transcription signature of hypoxia, angiogenesis, and oxidoreductase imbalance; (b) SDHB protein is suppressed in tumors with mutations in SDHB and SDHD, and also in a subset of tumors with VHL mutations; and (c) HIF1α is involved in the SDHB downregulation observed in these tumors. These results are consistent with the existence of a close interconnection between the VHL and SDH pathways mediated predominantly by hypoxia and oxidoreductase signals. It further suggests that low SDHB levels indicative of impaired mitochondrial complex II function may be a shared element of these pheochromocytomas. SDHB may thus constitute a marker for tumors with abnormal hypoxic profile.

Idioma originalEnglish (US)
Título de la publicación alojadaPheochromocytoma
Subtítulo de la publicación alojadaFirst International Symposium
EditorialBlackwell Publishing Inc.
Número de páginas13
ISBN (versión impresa)1573315974, 9781573315975
EstadoPublished - ago 2006

Serie de la publicación

NombreAnnals of the New York Academy of Sciences
ISSN (versión impresa)0077-8923
ISSN (versión digital)1749-6632

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Neuroscience
  • History and Philosophy of Science


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