Transatlantic progress in measurement of cognitive outcomes in paediatric oncology trials

Sophie Thomas; Leanne Embry; Karin Walsh; Kim Bull; Richard Grundy; Colin Kennedy; Jurgen Lemiere; Pablo Hernáiz Driever; Jennifer Limond; Mathilde Chevignard; Kristina Hardy

doi:10.1002/pbc.30171

Transatlantic progress in measurement of cognitive outcomes in paediatric oncology trials

Sophie Thomas, Leanne Embry, Karin Walsh, Kim Bull, Richard Grundy, Colin Kennedy, Jurgen Lemiere, Pablo Hernáiz Driever, Jennifer Limond, Mathilde Chevignard, Kristina Hardy

Resultado de la investigación: Article › revisión exhaustiva

Resumen

The importance of measuring quality of survival within paediatric oncology trials is increasingly recognised. However, capturing neuropsychological outcomes and other aspects of quality of survival in the context of large or multinational trials can be challenging. We provide examples of protocols designed to address this challenge recently employed in clinical trials in the USA and Europe. We discuss their respective strengths and challenges, obstacles encountered and future opportunities for transatlantic collaboration.

Idioma original	English (US)
Número de artículo	e30171
Publicación	Pediatric Blood and Cancer
Volumen	70
N.º	5
DOI	https://doi.org/10.1002/pbc.30171
Estado	Published - may 2023
Publicado de forma externa	Sí

ASJC Scopus subject areas

Hematology
Oncology
Pediatrics, Perinatology, and Child Health

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10.1002/pbc.30171

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abstract = "The importance of measuring quality of survival within paediatric oncology trials is increasingly recognised. However, capturing neuropsychological outcomes and other aspects of quality of survival in the context of large or multinational trials can be challenging. We provide examples of protocols designed to address this challenge recently employed in clinical trials in the USA and Europe. We discuss their respective strengths and challenges, obstacles encountered and future opportunities for transatlantic collaboration.",

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AU - Thomas, Sophie

AU - Embry, Leanne

AU - Walsh, Karin

AU - Bull, Kim

AU - Grundy, Richard

AU - Kennedy, Colin

AU - Lemiere, Jurgen

AU - Hernáiz Driever, Pablo

AU - Limond, Jennifer

AU - Chevignard, Mathilde

AU - Hardy, Kristina

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AB - The importance of measuring quality of survival within paediatric oncology trials is increasingly recognised. However, capturing neuropsychological outcomes and other aspects of quality of survival in the context of large or multinational trials can be challenging. We provide examples of protocols designed to address this challenge recently employed in clinical trials in the USA and Europe. We discuss their respective strengths and challenges, obstacles encountered and future opportunities for transatlantic collaboration.

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KW - cancer

KW - child

KW - cognitive

KW - late effects

KW - paediatric

KW - quality of survival

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Transatlantic progress in measurement of cognitive outcomes in paediatric oncology trials

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