Trajectories of psychological distress in adolescent and young adult patients with cancer: A 1-year longitudinal study

Minyoung Kwak, Brad J. Zebrack, Kathleen A. Meeske, Leanne Embry, Christine Aguilar, Rebecca Block, Brandon Hayes-Lattin, Yun Li, Melissa Butler, Steven Cole

Resultado de la investigación: Articlerevisión exhaustiva

151 Citas (Scopus)


Purpose: To examine prevalence and changes in symptoms of psychological distress over 1 year after initial cancer diagnosis in adolescent and young adult (AYA) patients with cancer. Sociodemographic and clinical predictors of changes in distress were examined. Patients and Methods: In this multisite, longitudinal, prospective study of an ethnically diverse sample, 215 patients age 14 to 39 years were assessed for psychological distress within the first 4 months of diagnosis and again 6 and 12 months later. Linear mixed models with random intercept and slope estimated changes in distress, as measured by the Brief Symptom Inventory-18 (BSI-18). Results: Within the first 4 months of diagnosis, 60 respondents (28%) had BSI-18 scores suggesting caseness for distress. On average, distress symptoms exceeded population norms at the time of diagnosis, dipped at the 6-month follow-up, but increased to a level exceeding population norms at the 12-month follow-up. A statistically significant decline in distress over 1 year was observed; however, the gradient of change was not clinically significant. Multivariate analyses revealed that the reduction in distress over time was primarily a function of being off treatment and involved in school or work. Notably, cancer type or severity was not associated with distress. Conclusion: Findings emphasize the importance of early psychosocial intervention for distress in AYAs as well as the need to manage treatment-related symptoms and facilitate AYAs’ involvement in work or school to the extent possible. Continued research is needed to understand how distress relates to quality of life, functional outcomes, treatment, and symptom burden throughout the continuum of care.

Idioma originalEnglish (US)
Páginas (desde-hasta)2160-2166
Número de páginas7
PublicaciónJournal of Clinical Oncology
EstadoPublished - jun 10 2013

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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