Toward understanding the role of methylation in aldosterone-sensitive Na⁺ transport

Proper endocrine regulation of Na⁺ reabsorption by renal principal cells is the primary means in mammals for maintaining blood pressure. Aldosterone increases Na⁺ reabsorption by activating luminal Na⁺ channels; however, the signal transduction pathway of aldosterone is not fully understood. Cellular methylation is necessary for aldosterone signaling to the luminal Na⁺ channel. We describe the enzymes, regulators, and effectors of aldosterone-mediated methylation relevant to Na⁺ reabsorption.