TY - JOUR
T1 - Toward individual glomerular phenotyping
T2 - advent of precision medicine in kidney biopsies
AU - Sharma, Kumar
AU - Paša-Tolić, Ljiljana
N1 - Publisher Copyright:
© 2018 International Society of Nephrology
PY - 2018/6
Y1 - 2018/6
N2 - The road to precision medicine for nephrology is approaching quickly. In the present volume, the glomerular proteome has now been characterized at a single glomerulus level in mouse and human kidneys. Using the Single-Pot Solid-Phase–enhanced Sample Preparation (SP3) approach the authors demonstrated that LAMP1 is a key lysosomal protein that is increased in glomerular diseases and may play a pathogenic role.
AB - The road to precision medicine for nephrology is approaching quickly. In the present volume, the glomerular proteome has now been characterized at a single glomerulus level in mouse and human kidneys. Using the Single-Pot Solid-Phase–enhanced Sample Preparation (SP3) approach the authors demonstrated that LAMP1 is a key lysosomal protein that is increased in glomerular diseases and may play a pathogenic role.
UR - http://www.scopus.com/inward/record.url?scp=85047003572&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047003572&partnerID=8YFLogxK
U2 - 10.1016/j.kint.2018.01.035
DO - 10.1016/j.kint.2018.01.035
M3 - Comment/debate
C2 - 29792268
AN - SCOPUS:85047003572
SN - 0085-2538
VL - 93
SP - 1265
EP - 1267
JO - Kidney International
JF - Kidney International
IS - 6
ER -