Toll-like receptors (TLRs) play a key role in innate immune defenses. After activation by foreign pathogens or host-derived molecules, TLRs signal via overlapping or distinct signaling cascades and eventually induce numerous genes involved in a variety of cellular responses. A growing body of evidence suggests that TLR signaling also plays an important role in cardiac ischemia/reperfusion injury. We review our current understanding of the TLR signaling pathways and their roles in the pathophysiology of cardiac ischemia/reperfusion injury, as well as discuss several mechanisms for TLR activation and regulation.
|Idioma original||English (US)|
|Número de páginas||10|
|Estado||Published - dic 2010|
|Publicado de forma externa||Sí|
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
- Emergency Medicine