Thyroid function and alzheimer's disease

Zaldy S. Tan, Ramachandran S. Vasan

Producción científica: Review articlerevisión exhaustiva

82 Citas (Scopus)

Resumen

Thyroid dysfunction has been implicated as a cause of reversible cognitive impairment and as such, the thyroid stimulating hormone has long been part of the screening laboratory test for dementia. Recently, several population-based studies demonstrated an association between hypo- or hyperthyroidism and Alzheimer's disease. This review discusses the role of thyroid hormone in the normal development and regulation of central nervous system functions and summarizes the studies that have linked thyroid function and dementia risk. Finally, it explores possible biological mechanisms to explain this association, including the direct effects of thyroid hormone on cerebral amyloid processing, neurodegeneration and thyrotropin-mediated mechanisms and vascular mediated enhancement of Alzheimer's disease risk.

Idioma originalEnglish (US)
Páginas (desde-hasta)503-507
Número de páginas5
PublicaciónJournal of Alzheimer's Disease
Volumen16
N.º3
DOI
EstadoPublished - 2009
Publicado de forma externa

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Clinical Psychology
  • General Neuroscience

Huella

Profundice en los temas de investigación de 'Thyroid function and alzheimer's disease'. En conjunto forman una huella única.

Citar esto