Therapeutic Applications of Melatonin in Pediatrics

Emilio J. Sanchez-Barcelo, Maria D. Mediavilla, Russel J. Reiter

Producción científica: Chapter


Melatonin actions described in experimental studies include the regulation of circadian rhythms (i.e., sleep/alertness or body temperature) (Arendt and Skene, 2005; Cagnacci et al., 1992), effects on reproductive physiology (Reiter et al., 2009), and antioxidant properties (Allegra et al., 2003) among other properties (Macchi and Bruce, 2004). This variety of actions has encouraged the study of its possible clinical applications in different pathologies. A review of the clinical trials carried out to assess the possible usefulness of melatonin as a therapeutic drug can be found in the article of Sanchez-Barcelo et al. (2010). Pediatrics is also listed among the medical areas investigating possible applications of melatonin. Gitto et al. (2011) and Sanchez-Barcelo et al. (2011) recently published review articles analyzing the clinical uses of melatonin in pediatrics. Since this book focuses on the neuroprotective effects of melatonin, we are now going to review the clinical uses of melatonin in pediatric pathologies involving the central neural system, including epilepsy and sleep disorders, as well as in clinical practices such as anesthesia.

Idioma originalEnglish (US)
Título de la publicación alojadaMelatonin
Subtítulo de la publicación alojadaTherapeutic Value and Neuroprotection
EditorialCRC Press
Número de páginas9
ISBN (versión digital)9781482220100
EstadoPublished - ene 1 2014

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology
  • General Neuroscience
  • General Agricultural and Biological Sciences
  • General Medicine


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