The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells

André Brannvoll, Xiaoyu Xue, Youngho Kwon, Smaragdi Kompocholi, Anne Katrine W. Simonsen, Keerthana S. Viswalingam, Leticia Gonzalez, Ian D. Hickson, Vibe H. Oestergaard, Hocine W. Mankouri, Patrick Sung, Michael Lisby

Producción científica: Articlerevisión exhaustiva

11 Citas (Scopus)

Resumen

DNA helicases are important for DNA repair processes. Here, Brannvoll et al. show that ZGRF1 is a 5′-to-3′ DNA helicase that promotes the resolution of replication-blocking DNA lesions by homologous recombination. ZGRF1 is recruited to sites of DNA damage and directly stimulates the RAD51 recombinase.

Idioma originalEnglish (US)
Número de artículo107849
PublicaciónCell Reports
Volumen32
N.º1
DOI
EstadoPublished - jul 7 2020

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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