The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents

P. M. Treuting, J. M. Snyder, Y. Ikeno, P. N. Schofield, J. M. Ward, J. P. Sundberg

Producción científica: Articlerevisión exhaustiva

24 Citas (Scopus)

Resumen

Pathology is a discipline of medicine that adds great benefit to aging studies of rodents by integrating in vivo, biochemical, and molecular data. It is not possible to diagnose systemic illness, comorbidities, and proximate causes of death in aging studies without the morphologic context provided by histopathology. To date, many rodent aging studies do not utilize end points supported by systematic necropsy and histopathology, which leaves studies incomplete, contradictory, and difficult to interpret. As in traditional toxicity studies, if the effect of a drug, dietary treatment, or altered gene expression on aging is to be studied, systematic pathology analysis must be included to determine the causes of age-related illness, moribundity, and death. In this Commentary, the authors discuss the factors that should be considered in the design of aging studies in mice, with the inclusion of robust pathology practices modified after those developed by toxicologic and discovery research pathologists. Investigators in the field of aging must consider the use of histopathology in their rodent aging studies in this era of integrative and preclinical geriatric science (geroscience).

Idioma originalEnglish (US)
Páginas (desde-hasta)244-249
Número de páginas6
PublicaciónVeterinary pathology
Volumen53
N.º2
DOI
EstadoPublished - mar 1 2016

ASJC Scopus subject areas

  • General Veterinary

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