The vertebrate phototransduction cascade: Amplification and termination mechanisms

Producción científica: Review articlerevisión exhaustiva

43 Citas (Scopus)


The biochemical cascade which transduces light into a neuronal signal in retinal photoreceptors is a heterotrimeric GTP-binding protein (G protein) signaling pathway called phototransduction. Works from psychophysicists, electrophysiologists, biochemists, and geneticists over several decades have come together to shape our understanding of how photon absorption leads to photoreceptor membrane hyperpolarization. The insights of phototransduction provide the foundation for a mechanistic account of signaling from many other G protein-coupled receptors (GPCR) found throughout nature. The application of reverse genetic techniques has strengthened many historic findings and helped to describe this pathway at greater molecular details. However, many important questions remain to be answered.

Idioma originalEnglish (US)
Páginas (desde-hasta)101-121
Número de páginas21
PublicaciónErgebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie
EstadoPublished - 2005
Publicado de forma externa

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Pharmacology
  • Physiology (medical)


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