The temporal relationship between antibiotic and opioid prescription on the risk of developing an opioid use disorder: A national database study

Peter Shafeek, Taylor Clegg, Noor Kawmi, Sierra Luciano, Curtis Bone, Nicholas Graziane

Producción científica: Articlerevisión exhaustiva

Resumen

Background: Previously, we discovered that subjects co-prescribed both antibiotics and opioids on the same day in a hospital setting displayed an increased risk of developing an opioid use disorder (OUD) 12 months following hospital discharge. The goal of this study was to examine whether prescribing antibiotics in the inpatient or emergency department setting at various time points before or after an opioid prescription impacted the risk OUD.Methods: A propensity score matched cohort study was conducted to identify subjects (18–65 years old) with no previous history of OUD. Two cohorts were defined: subjects who were prescribed antibiotics 0–1, 2–4, 5–7, 8–10, 11–12 months before or after the date of an opioid prescription while in the emergency department or inpatient setting, from the years 2010–2019. The diagnosis of an Opioid Related Disorder (F11.10–F11.20) 12 months following discharge from the emergency department or inpatient unit was then observed.Results: Primary analysis showed that subjects prescribed an antibiotic 0–1 month or 8–10 months before an opioid prescription showed a modest risk of developing an OUD 12 months following an opioid prescription (0.04% and 0.20%, respectively). Similarly, subjects prescribed an antibiotic 0–1 month, 5–7 months, or 8–10 months after an opioid prescription displayed a modest risk of developing OUD 12 months after an opioid prescription (0.02% risk, 0.14% risk, and 0.16% risk, respectively).Conclusions: These findings suggest that there is little to no effect on the risk of developing OUD when antibiotics are prescribed at various time points before or after opioid prescription.

Idioma originalEnglish (US)
Páginas (desde-hasta)274-281
Número de páginas8
PublicaciónJournal of Addictive Diseases
Volumen41
N.º4
DOI
EstadoPublished - 2023
Publicado de forma externa

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health

Huella

Profundice en los temas de investigación de 'The temporal relationship between antibiotic and opioid prescription on the risk of developing an opioid use disorder: A national database study'. En conjunto forman una huella única.

Citar esto