TY - JOUR
T1 - The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy
AU - Bieniek, Kevin F.
AU - Cairns, Nigel J.
AU - Crary, John F.
AU - Dickson, Dennis W.
AU - Folkerth, Rebecca D.
AU - Keene, C. Dirk
AU - Litvan, Irene
AU - Perl, Daniel P.
AU - Stein, Thor D.
AU - Vonsattel, Jean Paul
AU - Stewart, William
AU - Dams-O'connor, Kristen
AU - Gordon, Wayne A.
AU - Tripodis, Yorghos
AU - Alvarez, Victor E.
AU - Mez, Jesse
AU - Alosco, Michael L.
AU - Mckee, Ann C.
AU - Babcock, Debra
AU - Bellgowan, Patrick
AU - Crane, Paul
AU - Edlow, Brian
AU - Huber, Bertrand Russ
AU - Kiernan, Patrick
AU - Koroshetz, Walter
N1 - Publisher Copyright:
© 2021 Oxford University Press. All rights reserved.
PY - 2021/3/1
Y1 - 2021/3/1
N2 - Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB defined preliminary consensus neuropathological criteria for CTE, including the pathognomonic lesion of CTE as "an accumulation of abnormal hyperphosphorylated tau (p-tau) in neurons and astroglia distributed around small blood vessels at the depths of cortical sulci and in an irregular pattern," based on review of 25 tauopathy cases. In 2016, the consensus panel met again to review and refine the preliminary criteria, with consideration around the minimum threshold for diagnosis and the reproducibility of a proposed pathological staging scheme. Eight neuropathologists evaluated 27 cases of tauopathies (17 CTE cases), blinded to clinical and demographic information. Generalized estimating equation analyses showed a statistically significant association between the raters and CTE diagnosis for both the blinded (OR = 72.11, 95% CI = 19.5-267.0) and unblinded rounds (OR = 256.91, 95% CI = 63.6-1558.6). Based on the challenges in assigning CTE stage, the panel proposed a working protocol including a minimum threshold for CTE diagnosis and an algorithm for the assessment of CTE severity as "Low CTE" or "High CTE" for use in future clinical, pathological, and molecular studies.
AB - Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB defined preliminary consensus neuropathological criteria for CTE, including the pathognomonic lesion of CTE as "an accumulation of abnormal hyperphosphorylated tau (p-tau) in neurons and astroglia distributed around small blood vessels at the depths of cortical sulci and in an irregular pattern," based on review of 25 tauopathy cases. In 2016, the consensus panel met again to review and refine the preliminary criteria, with consideration around the minimum threshold for diagnosis and the reproducibility of a proposed pathological staging scheme. Eight neuropathologists evaluated 27 cases of tauopathies (17 CTE cases), blinded to clinical and demographic information. Generalized estimating equation analyses showed a statistically significant association between the raters and CTE diagnosis for both the blinded (OR = 72.11, 95% CI = 19.5-267.0) and unblinded rounds (OR = 256.91, 95% CI = 63.6-1558.6). Based on the challenges in assigning CTE stage, the panel proposed a working protocol including a minimum threshold for CTE diagnosis and an algorithm for the assessment of CTE severity as "Low CTE" or "High CTE" for use in future clinical, pathological, and molecular studies.
KW - Brain trauma
KW - Chronic traumatic encephalopathy
KW - Neurodegenerative disorders
KW - Tauopathy
KW - Traumatic brain injury
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U2 - 10.1093/jnen/nlab001
DO - 10.1093/jnen/nlab001
M3 - Article
C2 - 33611507
AN - SCOPUS:85103306629
SN - 0022-3069
VL - 80
SP - 210
EP - 219
JO - Journal of Neuropathology and Experimental Neurology
JF - Journal of Neuropathology and Experimental Neurology
IS - 3
ER -