The roles of orphan nuclear receptors in the development and function of the immune system.

Ivan Dzhagalov, N. Zhang, You Wen He

Producción científica: Review articlerevisión exhaustiva

33 Citas (Scopus)

Resumen

Hormones and their receptors regulate cell growth, differentiation and apoptosis and also play important roles in immune function. Recent studies on the subfamily of the orphan nuclear receptors known as retinoid-acid related orphan receptors (ROR) have shed important insights on the roles of this group of nuclear proteins in the development and function of the immune system. RORalpha regulates inflammatory cytokine production in both innate and adaptive immune system while RORgamma regulates the normal development of T lymphocyte repertoire and secondary lymphoid organs.

Idioma originalEnglish (US)
Páginas (desde-hasta)401-407
Número de páginas7
PublicaciónCellular & molecular immunology
Volumen1
N.º6
EstadoPublished - dic 2004
Publicado de forma externa

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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