Resumen
Orthodontic tooth movement is dependent on osteoclast activity. Tumor necrosis factor (TNF)-α plays an important role, directly or via chemokine release, in osteoclast recruitment and activation. This study aimed to investigate whether the TNF receptor type 1 (p55) influences these events and, consequently, orthodontic tooth movement. An orthodontic appliance was placed in wild-type mice (WT) and p55-deficient mice (p55-/-). Levels of TNF-α and 2 chemokines (MCP-1/CCL2, RANTES/CCL5) were evaluated in periodontal tissues. A significant increase in CCL2 and TNF-α was observed in both groups after 12 hrs of mechanical loading. However, CCL5 levels remained unchanged in p55-/- mice at this time-point. The number of TRAP-positive osteoclasts in p55-/- mice was significantly lower than that in WT mice. Also, there was a significantly smaller rate of tooth movement in p55-/- mice. Analysis of our data suggests that the TNFR-1 plays a significant role in orthodontic tooth movement that might be associated with changes in CCL5 levels.
Idioma original | English (US) |
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Páginas (desde-hasta) | 1089-1094 |
Número de páginas | 6 |
Publicación | Journal of dental research |
Volumen | 86 |
N.º | 11 |
DOI | |
Estado | Published - nov 2007 |
Publicado de forma externa | Sí |
ASJC Scopus subject areas
- General Dentistry