The role of the microenvironment and intercellular cross-talk in tumor angiogenesis

Syed A. Ahmad, Young D. Jung, Wenbiao Liu, Neils Reinmuth, Alexander Parikh, Oliver Stoeltzing, Fan Fan, Lee M. Ellis

Producción científica: Articlerevisión exhaustiva

100 Citas (Scopus)

Resumen

The expression of angiogenic factors in tumors is controlled by intrinsic factors in the tumor and by the host microenvironment. Endothelial cells within particular tumor microenvironments interact not only with tumor cells but also with immune cells, fibroblasts, pericytes, and the extracellular matrix (ECM). The relationship and cross-talk among these cells determine gene expression, phenotypic distinction, and ultimately whether endothelial cells survive, proliferate, or undergo apoptosis. The diversity of angiogenic factor expression in tumors at different sites, combined with the fact that endothelial cells in different organs and tumors are phenotypically distinct, constitutes a formidable challenge for the development of effective anti-angiogenic therapies.

Idioma originalEnglish (US)
Páginas (desde-hasta)105-112
Número de páginas8
PublicaciónSeminars in Cancer Biology
Volumen12
N.º2
DOI
EstadoPublished - abr 2002
Publicado de forma externa

ASJC Scopus subject areas

  • Cancer Research

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