The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo

Dun Xian Tan; Burkhard Pöeggeler; Russel J. Reiter; Li Dun Chen; Shou Chen; Manchester C. Lucien; Lornell R. Barlow-Walden

doi:10.1016/0304-3835(93)90076-L

The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo

Dun Xian Tan
, Burkhard Pöeggeler
, Russel J. Reiter
, Li Dun Chen
, Shou Chen
, Manchester C. Lucien
, Lornell R. Barlow-Walden

Producción científica: Article › revisión exhaustiva

307 Citas (Scopus)

Resumen

Melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in a dose-dependent manner. Total DNA-adduct formation after in vivo administration of 300 mg/kg safrole measured by ³²P-postlabeling analysis of carcinogen-modified DNA in rat liver was 36 751 ± 2290 counts/min/10 μg DNA. Coad-ministration of 300 mg/kg safrole with either 0.2 mg/kg (low dose) or 0.4 mg/kg (high dose) melatonin reduced DNA-adduct formation induced by safrole to 22 182 ± 987 counts/min/10 μg DNA and 462 ± 283 counts/min/10 μg DNA, respectively. Circulating melatonin concentrations at the termination of the study in safrole, low melatonin and high melatonin groups were 50 ± 8, 3140 ± 430 and 10 040 ± 2610 pg/ml serum, respectively. The results suggest that melatonin protects against safrole associated DNA damage.

Idioma original	English (US)
Páginas (desde-hasta)	65-71
Número de páginas	7
Publicación	Cancer Letters
Volumen	70
N.º	1-2
DOI	https://doi.org/10.1016/0304-3835(93)90076-L
Estado	Published - jun 15 1993

ASJC Scopus subject areas

Oncology
Cancer Research

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@article{7aeefe6cdbc74478849ad65c3052a458,

title = "The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo",

abstract = "Melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in a dose-dependent manner. Total DNA-adduct formation after in vivo administration of 300 mg/kg safrole measured by 32P-postlabeling analysis of carcinogen-modified DNA in rat liver was 36 751 ± 2290 counts/min/10 μg DNA. Coad-ministration of 300 mg/kg safrole with either 0.2 mg/kg (low dose) or 0.4 mg/kg (high dose) melatonin reduced DNA-adduct formation induced by safrole to 22 182 ± 987 counts/min/10 μg DNA and 462 ± 283 counts/min/10 μg DNA, respectively. Circulating melatonin concentrations at the termination of the study in safrole, low melatonin and high melatonin groups were 50 ± 8, 3140 ± 430 and 10 040 ± 2610 pg/ml serum, respectively. The results suggest that melatonin protects against safrole associated DNA damage.",

keywords = "DNA adduct, carcinogen, melatonin, safrole",

author = "Tan, \{Dun Xian\} and Burkhard P{\"o}eggeler and Reiter, \{Russel J.\} and Chen, \{Li Dun\} and Shou Chen and Lucien, \{Manchester C.\} and Barlow-Walden, \{Lornell R.\}",

note = "Funding Information: This work was supportedb y NSF IBN 9121262to RJR.",

year = "1993",

month = jun,

day = "15",

doi = "10.1016/0304-3835(93)90076-L",

language = "English (US)",

volume = "70",

pages = "65--71",

journal = "Cancer Letters",

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TY - JOUR

T1 - The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo

AU - Tan, Dun Xian

AU - Pöeggeler, Burkhard

AU - Reiter, Russel J.

AU - Chen, Li Dun

AU - Chen, Shou

AU - Lucien, Manchester C.

AU - Barlow-Walden, Lornell R.

N1 - Funding Information: This work was supportedb y NSF IBN 9121262to RJR.

PY - 1993/6/15

Y1 - 1993/6/15

N2 - Melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in a dose-dependent manner. Total DNA-adduct formation after in vivo administration of 300 mg/kg safrole measured by 32P-postlabeling analysis of carcinogen-modified DNA in rat liver was 36 751 ± 2290 counts/min/10 μg DNA. Coad-ministration of 300 mg/kg safrole with either 0.2 mg/kg (low dose) or 0.4 mg/kg (high dose) melatonin reduced DNA-adduct formation induced by safrole to 22 182 ± 987 counts/min/10 μg DNA and 462 ± 283 counts/min/10 μg DNA, respectively. Circulating melatonin concentrations at the termination of the study in safrole, low melatonin and high melatonin groups were 50 ± 8, 3140 ± 430 and 10 040 ± 2610 pg/ml serum, respectively. The results suggest that melatonin protects against safrole associated DNA damage.

AB - Melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in a dose-dependent manner. Total DNA-adduct formation after in vivo administration of 300 mg/kg safrole measured by 32P-postlabeling analysis of carcinogen-modified DNA in rat liver was 36 751 ± 2290 counts/min/10 μg DNA. Coad-ministration of 300 mg/kg safrole with either 0.2 mg/kg (low dose) or 0.4 mg/kg (high dose) melatonin reduced DNA-adduct formation induced by safrole to 22 182 ± 987 counts/min/10 μg DNA and 462 ± 283 counts/min/10 μg DNA, respectively. Circulating melatonin concentrations at the termination of the study in safrole, low melatonin and high melatonin groups were 50 ± 8, 3140 ± 430 and 10 040 ± 2610 pg/ml serum, respectively. The results suggest that melatonin protects against safrole associated DNA damage.

KW - DNA adduct

KW - carcinogen

KW - melatonin

KW - safrole

UR - https://www.scopus.com/pages/publications/0027201993

UR - https://www.scopus.com/pages/publications/0027201993#tab=citedBy

U2 - 10.1016/0304-3835(93)90076-L

DO - 10.1016/0304-3835(93)90076-L

M3 - Article

C2 - 8330303

AN - SCOPUS:0027201993

SN - 0304-3835

VL - 70

SP - 65

EP - 71

JO - Cancer Letters

JF - Cancer Letters

IS - 1-2

ER -

The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo

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