The Physiology of Early Goal-Directed Therapy for Sepsis

Lindsay Lief, John Arbo, David A. Berlin

Producción científica: Review articlerevisión exhaustiva

1 Cita (Scopus)


In 2001, Rivers and colleagues published a randomized controlled trial of early goal-directed therapy (EGDT) for the treatment of sepsis. More than a decade later, it remains a landmark achievement. The study proved the benefits of early aggressive treatment of sepsis. However, many questions remain about specific aspects of the complex EGDT algorithm. Recently, 3 large trials attempted to replicate these results. None of the studies demonstrated a benefit of an EGDT protocol for sepsis. This review explores the physiologic basis of goal-directed therapy, including the hemodynamic targets and the therapeutic interventions. An understanding of the physiologic basis of EGDT helps reconcile the results of the clinical trials.

Idioma originalEnglish (US)
Páginas (desde-hasta)567-573
Número de páginas7
PublicaciónJournal of Intensive Care Medicine
EstadoPublished - dic 1 2017
Publicado de forma externa

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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