Resumen
In 2001, Rivers and colleagues published a randomized controlled trial of early goal-directed therapy (EGDT) for the treatment of sepsis. More than a decade later, it remains a landmark achievement. The study proved the benefits of early aggressive treatment of sepsis. However, many questions remain about specific aspects of the complex EGDT algorithm. Recently, 3 large trials attempted to replicate these results. None of the studies demonstrated a benefit of an EGDT protocol for sepsis. This review explores the physiologic basis of goal-directed therapy, including the hemodynamic targets and the therapeutic interventions. An understanding of the physiologic basis of EGDT helps reconcile the results of the clinical trials.
Idioma original | English (US) |
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Páginas (desde-hasta) | 567-573 |
Número de páginas | 7 |
Publicación | Journal of Intensive Care Medicine |
Volumen | 32 |
N.º | 10 |
DOI | |
Estado | Published - dic 1 2017 |
Publicado de forma externa | Sí |
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine