The Phosphoinositide-3 kinase survival signaling mechanism in sepsis

Mariuxi C. Manukyan, Brent R. Weil, Yue Wang, Aaron M. Abarbanell, Jeremy L. Herrmann, Jeffrey A. Poynter, Daniel R. Meldrum

Resultado de la investigación: Review articlerevisión exhaustiva


Phosphoinositide-3 kinases (PI3Ks) are critical regulatory proteins in the immunologic defense system against sepsis. The PI3K mechanism helps modulate cellular survival, innate and adaptive immunities, inflammation, nuclear factor-κB transcription, and may, in turn, play a protective role in sepsis. Animal studies confirm its role in the prevention of organ dysfunction and improvement of survival outcomes. Further advances in the understanding of this key immunomodulatory pathway may provide valuable insights into the manipulation of cellular function for therapeutic treatment of sepsis and other inflammatory diseases.

Idioma originalEnglish (US)
Páginas (desde-hasta)442-449
Número de páginas8
EstadoPublished - nov 2010
Publicado de forma externa

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine


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