The non-human primate kidney transcriptome in fetal development

Kimberly D. Spradling-Reeves, Jeremy P. Glenn, Kenneth J. Lange, Natalia Kuhn, Jacqueline J Coalson, Mark J. Nijland, Cun Li, Peter W. Nathanielsz, Laura Cox

Resultado de la investigación: Articlerevisión exhaustiva

2 Citas (Scopus)


Background: Little is known about the repertoire of non-human primate kidney genes expressed throughout development. The present work establishes an understanding of the primate renal transcriptome during fetal development in the context of renal maturation. Methods: The baboon kidney transcriptome was characterized at 60-day gestation (DG), 90 DG, 125 DG, 140 DG, 160 DG and adulthood (6-12 years) using gene arrays and validated by QRT-PCR. Pathway and cluster analyses were used to characterize gene expression in the context of biological pathways. Results: Pathway analysis indicated activation of pathways not previously reported as relevant to kidney development. Cluster analysis also revealed gene splice variants with discordant expression profiles during development. Conclusions: This study provides the first detailed genetic analysis of the developing primate kidney, and our findings of discordant expression of gene splice variants suggest that gene arrays likely provide a simplified view and demonstrate the need to study the fetal renal proteome.

Idioma originalEnglish (US)
Páginas (desde-hasta)157-171
Número de páginas15
PublicaciónJournal of medical primatology
EstadoPublished - jun 2018

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)


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