The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk

Matthew Nayor, Kemar J. Brown, Ramachandran S. Vasan

Producción científica: Review articlerevisión exhaustiva

47 Citas (Scopus)

Resumen

Atherosclerotic cardiovascular disease (ASCVD) proceeds through a series of stages: initiation, progression (or regression), and complications. By integrating known biology regarding molecular signatures of each stage with recent advances in high-dimensional molecular data acquisition platforms (to assay the genome, epigenome, transcriptome, proteome, metabolome, and gut microbiome), snapshots of each phase of atherosclerotic cardiovascular disease development can be captured. In this review, we will summarize emerging approaches for assessment of atherosclerotic cardiovascular disease risk in humans using peripheral blood molecular signatures and molecular imaging approaches. We will then discuss the potential (and challenges) for these snapshots to be integrated into a personalized movie providing dynamic readouts of an individual's atherosclerotic cardiovascular disease risk status throughout the life course.

Idioma originalEnglish (US)
Páginas (desde-hasta)287-303
Número de páginas17
PublicaciónCirculation research
Volumen128
N.º2
DOI
EstadoPublished - ene 22 2021
Publicado de forma externa

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

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