The MAM rodent model of schizophrenia

Resultado de la investigación: Articlerevisión exhaustiva

39 Citas (Scopus)


Rodent models of human disease are essential to obtain a better understanding of disease pathology, the mechanism of action underlying conventional treatments, as well as for the generation of novel therapeutic approaches. There are a number of rodent models of schizophrenia based on either genetic manipulations, acute or sub-chronic drug administration, or developmental disturbances. The prenatal methylazoxymethanol acetate (MAM) rodent model is a developmental disruption model gaining increased attention because it displays a number of histological, neurophysiological, and behavioral deficits analogous to those observed in schizophrenia patients. This unit describes the procedures required to safely induce the MAM phenotype in rats. In addition, we describe a simple behavioral procedure, amphetamine-induced hyperlocomotion, which can be utilized to verify the MAM phenotype.

Idioma originalEnglish (US)
Número de artículo9.43
PublicaciónCurrent Protocols in Neuroscience
EstadoPublished - 2013

ASJC Scopus subject areas

  • Neuroscience(all)


Profundice en los temas de investigación de 'The MAM rodent model of schizophrenia'. En conjunto forman una huella única.

Citar esto